PNAS: study reveals how MHC dynamically binds antigen peptides
As one of the two primary classes of major histocompatibility complex (MHC) molecules, MHC class I molecules are expressed in almost all cell types and can present peptide antigens to …
GLP-1 drugs are expected to replace insulin to be the best choice for first-line treatment
Diabetes mellitus (DM) is a group of metabolic diseases classified by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Diabetes is prevalent worldwide and the number …
The first mechanism-based septic shock therapy!
Recently, Inotrem S.A. announced that the US Food and Drug Administration (FDA) has granted nangibotide (LR12) Fast Track designation (FTD) for the treatment of septic shock. Septic shock is the …
How do new peptide molecules improve human health?
Scientists are expected to develop a new type of cellular permeable peptide chimera to promote wound healing. In recent years, cell penetrating peptides as drug delivery carriers have aroused great …
Peptides can be synthesized without amino acids
Amide bond formation is one of the most important reactions in chemistry and biology, but there is no chemical way to achieve α-peptide ligation in water without using all 20 …
The latest research report of Semaglutide
Novo Nordisk recently presented the latest data from two phase 3a clinical trials of its oral Semaglutide at the annual (ADA) meeting of the American Diabetes Association. Compared with the …
Peptide drugs from poisons
Some of the deadliest animals on earth are toxic. Poison is their deadly weapon to defend themselves or attack. Toxins are injected into the skin and become poison. There are …
Sulforaphane, an anticancer substance.
Sulforaphane, chemical name is 1-isothiocyanate-4-methanesulfonyl butane, also known as “sulforaphane”, which is a common antioxidant and rich in broccoli, cabbage, broccoli, kale, carrots, and other cruciferous plants. Some research showed …
Scientists identify potential target protein aggregates for Alzheimer’s disease.
Recently, a study published in the international journal Stem Cell Reports, Scientists from institutions such as the University of Paris IV have identified potential targets for the treatment of Alzheimer’s …
Progress of several anti-aging therapies
For thousands of years, a human has never stopped chasing the dream of “immortality”. With the development of biology, we have a new understanding of the word “immortality” and recognize the …