Progress of several anti-aging therapies
For thousands of years, a human has never stopped chasing the dream of “immortality”. With the development of biology, we have a new understanding of the word “immortality” and recognize the …
Alzheimer’s disease and β-amyloid protein
Alzheimer’s disease (AD) is the most common cause of dementia and is considered the biggest public health hazard of our generation, affecting more than 20 million people. About 135 million …
Alzheimer’s disease and diabetes: hope for inhibitors against amyloid plaques
Amyloid self-assembly is linked to the pathogenesis of Alzheimer’s disease (AD) and type Ⅱ diabetes (T2D), Several teams of scientists around the world are working on finding ways to prevent amyloid plaque …
Agonists and antagonists for NPY-family receptors
Peptide ligands Over the past four years there’s been considerable progress in the development of novel selective analogs of NPY. A number of these analogs have been directed toward discovering tools to …
The application of Peptide nucleic acids (PNAs)
The definition of Peptide nucleic acids (PNAs) PNAs are synthetic DNA analogs in which the phosphodiester backbone is replaced by repetitive units of N-(2-aminoethyl) glycine to which the purine and pyrimidine bases …
Novel neuropeptide may hold clues to the risk of obesity and diabetes
Obesity is a chronic, multidimensional problem which is being increasingly seen in younger patients. Besides obesity is becoming an epidemic in industrialized countries and is continuing to increase in developing …
Peptide Therapies in Diabetes Mellitus
Diabetes mellitus is a metabolic syndrome that is defined by raised plasma glucose levels, accompanied by complete or partial deficiency of insulin. Type II diabetes contributes to more than 90 % of …
Structure and function of amyloid
The term ‘amyloid’ was first used in 1854 by Rudolph Virchow to describe abnormal brain tissue that was stained by iodine, suggesting that it was starch-like. It was later discovered that the amyloid …
Therapeutic Peptides
Peptides & Proteins as Therapuetics The most frequently used peptide/protein drugs can be classified in three main groups. Group I includes exogenously administered protein drugs in case of a deficiency. …
Neuropeptide Y
Neuropeptide Y (NPY) is a 36 amino acid, C-terminally amidated peptide. It is called Neuropeptide (Y) due to its abundance in the central and peripheral nervous system, and its high number …