PMX-53 is an effective c5a receptor antagonist (ic50 = 20 nm), which inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis. It also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells.
CAT# | R0880 |
CAS | 219639-75-5 |
Synonyms/Alias | PMX 53;Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg |
M.F/Formula | C47H65N11O7 |
M.W/Mr. | 896.1 |
Sequence | FXPXWR(Modifications: Phe-1 = N-terminal Ac, X-2 = Orn, X-4 = D-Cha, Lactam bridge: Orn-2 to Arg-6 ) |
Labeling Target | C5a receptor |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Antagonist |
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