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Pharmaceutical products are formulated products with specific dosage forms for efficient delivery and product stability. Formulation development serves the purpose to determine the optimal dosage form, composition and manufacturing route for pharmaceutical products.
They require different production technologies and at the same time present different challenges for the study. DOE (design of experiments) is used as a routine for formulation development, and it evaluates all potential factors simultaneously, systematically, and quickly.
A formulation contains the active pharmaceutical ingredient (API) and other inactive excipients.
Creative Peptides offers quality solutions for the development and production of liquid and solid pharmaceutical formulations, including but not limited:
Due to the specific interaction of peptides with their targets, peptides can exhibit increased potency and selectivity, with the potential to reduce off-target side effects and lower systemic toxicity. However, the disadvantages of peptide drugs, such as low oral bioavailability, poor membrane permeability and metabolic barriers, limit their wide application. Therefore, formulation development of peptide drug molecules is particularly critical, and the development of new drug delivery technologies has stimulated great potential for peptide therapies.
|Stability risk||Formulation strategy|
|Solubility||Optimization of ionic strength|
|Addition of solubilizing excipients|
|Hydrolysis||Addition of buffer excipients to control pH|
|Oxidation||Addition of antioxidants|
|Addition of chelating agents|
|Maintenance of pH<7|
|Aggregation||Addition of buffer excipients|
|Optimization of ionic strength|
|Addition of surfactants, co-solvents|
|Adsorption||Addition of surfactant and polymer excipients|
|Addition of albumin|
|Denaturation||Addition of salts or metal ions|
|Microbial contamination||Addition of preservative excipients|
All equipment in the production area is in compliance with cGMP.
Creative Peptides offers design and optimization of formulations from early pre-clinical stage to Phase I and Phase II clinical trials and commercial manufacturing. We are dedicated to help you achieve the optimal formulation for your APIs.
Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!
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