Peptide-RNA Conjugation

Creative Peptides provides high-quality Peptide-RNA conjugates through selective cross-linking chemical reactions. Creative Peptides offers a wide range of synthesis scales, modifications and purifications to customize your strict requirements for Peptide-RNA Conjugation.

Introduction of Peptide-RNA Conjugation

Peptide-RNA conjugate is considered a useful drug because its stability is much better than RNA. Methods for preparing peptide-RNA conjugates include: post-synthesis coupling method (or post-assembly coupling method and fragment coupling method), fully stepwise synthesis method (or online solid-phase synthesis method), natural coupling method and template orientation coupling method. For Peptide-RNA conjugates, 2'-O-methyl RNA is a recommended analog, which is resistant to degradation by single-stranded ribonuclease. Creative Peptides uses click chemistry to synthesize Peptide-RNA conjugates. Both peptides and oligonucleotides are first modified to perform biological orthogonal ligation reactions. These peptide-RNA conjugates are becoming more and more important in antisense therapy because they are identified as active carriers that can enhance the cell delivery of antisense oligonucleotides. RNA and peptide synthesis are produced and conjugated by our expert scientists in biological binding chemistry. According to strict biosynthesis quality assurance and quality control standards, every peptide-RNA conjugate is strictly monitored in every production cycle.

Application of Peptide-RNA Conjugation

Peptide-RNA conjugate is an important tool for studying protein-nucleic acid and peptide-nucleic acid, and also a promising biological conjugate for nucleic acid transport and therapy.

Peptide-RNA Conjugation can be used for: cancer immunotherapy technology, CRISPR / genome editing, liquid biopsy, single cell analysis, nanopore sequencing, nanoparticle drug delivery and structure-based drug design.

Peptide-RNA conjugates also have certain potential in the treatment of siRNA, cell penetrating peptides and aptamers.

The customized Peptide-RNA Conjugation service provided by Creative Peptides has been widely used in detection development, such as hybridization detection, FISH, chip detection, cell imaging, in vivo imaging and homogeneous DNA detection.

Our Services

• Double-stranded RNA-peptide conjugation
• Coupling of single amino acid to RNA
• Coupling of peptides to siRNA
• Labeling of peptide-RNA conjugates with fluorescent dye or other modifications

Our Advantages

• Fully traceable documentation system
• Innovative products
• High quality service
• High repeatability between batches
• Product quality is stable and reliable
• Low sales price

Reference

1. Ameta, S. , Becker, J. , & Jaeschke, A. . (2014). Rna-peptide conjugate synthesis by inverse-electron demand diels-alder reaction. Organic & Biomolecular Chemistry, 12(26), 4701-4707.