Creative Peptides provides high-quality Peptide-RNA conjugates through selective cross-linking chemical reactions. Creative Peptides offers a wide range of synthesis scales, modifications and purifications to customize your strict requirements for Peptide-RNA Conjugation.
Peptide-RNA conjugate is considered a useful drug because its stability is much better than RNA. Methods for preparing peptide-RNA conjugates include: post-synthesis coupling method (or post-assembly coupling method and fragment coupling method), fully stepwise synthesis method (or online solid-phase synthesis method), natural coupling method and template orientation coupling method. For Peptide-RNA conjugates, 2'-O-methyl RNA is a recommended analog, which is resistant to degradation by single-stranded ribonuclease. Creative Peptides uses click chemistry to synthesize Peptide-RNA conjugates. Both peptides and oligonucleotides are first modified to perform biological orthogonal ligation reactions. These peptide-RNA conjugates are becoming more and more important in antisense therapy because they are identified as active carriers that can enhance the cell delivery of antisense oligonucleotides. RNA and peptide synthesis are produced and conjugated by our expert scientists in biological binding chemistry. According to strict biosynthesis quality assurance and quality control standards, every peptide-RNA conjugate is strictly monitored in every production cycle.
Peptide-RNA conjugate is an important tool for studying protein-nucleic acid and peptide-nucleic acid, and also a promising biological conjugate for nucleic acid transport and therapy.
Peptide-RNA Conjugation can be used for: cancer immunotherapy technology, CRISPR / genome editing, liquid biopsy, single cell analysis, nanopore sequencing, nanoparticle drug delivery and structure-based drug design.
Peptide-RNA conjugates also have certain potential in the treatment of siRNA, cell penetrating peptides and aptamers.
The customized Peptide-RNA Conjugation service provided by Creative Peptides has been widely used in detection development, such as hybridization detection, FISH, chip detection, cell imaging, in vivo imaging and homogeneous DNA detection.
Peptide-RNA conjugates are compounds formed by attaching peptides to RNA molecules using selective chemical reactions. These conjugates are synthesized using methods like post-synthesis coupling, solid-phase synthesis, and click chemistry for enhanced stability and cell delivery.
Peptide-RNA conjugates are crucial for studying protein-nucleic acid interactions, gene editing technologies like CRISPR, and RNA-based therapies. They also play a role in applications such as liquid biopsy, single-cell analysis, and nanoparticle drug delivery.
Peptide-RNA conjugates provide better stability than RNA alone, as the peptides protect the RNA from degradation by ribonucleases. This stability makes them more effective for therapeutic applications and drug delivery.
Peptide-RNA conjugates facilitate efficient delivery of antisense oligonucleotides and siRNA, helping to overcome challenges like cell membrane penetration. This makes them promising tools for gene therapy, including gene silencing and gene editing.
Yes, Peptide-RNA conjugates can be labeled with fluorescent dyes for applications like cell imaging, in vivo imaging, and hybridization detection. They enable high-resolution molecular imaging and offer potential for tracking RNA molecules in living systems.
Peptide-RNA conjugates can be modified with various functional groups, including fluorescent dyes and other chemical modifications, to enhance their detection, stability, or delivery capabilities. These modifications enable a wide range of applications in research and diagnostics.
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