Protected Amino Acids

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

CAT# Product Name M.W Molecular Formula Inquiry
CP00105 Boc-D-Alanine 189.2 Inquiry
CP00106 Boc-L-Alanine 189.2 C8H15NO4 Inquiry
CP00107 Boc-L-Alanine benzyl ester 279.3 C15H21NO4 Inquiry
CP00108 Boc-D-Alanine methyl ester 203.2 C9H17NO4 Inquiry
CP00109 Boc-L-Alanine N-hydroxysuccinimde ester 286.3 C12H18N2O6 Inquiry
CP00110 Boc-L-Alanine N-carboxyanhydride 215.2 Inquiry
CP00113 Fmoc-D-Alanine 311.33 C18H17NO4 Inquiry
CP00114 Fmoc-L-Alanine 311.33 C18H17NO4 Inquiry
CP00115 Fmoc-L-Alanine N-carboxyanhydride 337.3 Inquiry
CP00138 Boc-N-α-Methyl-L-alanine 203.2 C9H17NO4 Inquiry
CP00206 N-α-Boc-D-Arginine hydrochloride monohydrate 328.8 C11H25ClN4O5 Inquiry
CP00207 N-α-Boc-L-Arginine hydrochloride monohydrate 328.81 C11H23ClN4O4 Inquiry
CP00208 N-α-Boc-N-ω-,N-ω′-di-Z-L-arginine 542.6 C27H34N4O8 Inquiry
CP00209 N-α-Boc-N-ω-4-methoxy-2,3,6-trimethyl 486.6 C21H34N4O7S Inquiry
CP00211 N-α-Boc-N-ω-nitro-D-arginine 319.3 C11H21N5O6 Inquiry
CP00212 N-α-Boc-N-ω-nitro-L-arginine 319.3 C11H21N5O6 Inquiry
CP00213 N-α-Boc-N-ω-tosyl-D-arginine 428.4 C14H18N2O6 Inquiry
CP00214 N-α-Fmoc-D-Arginine 396.5 C21H24N4O4 Inquiry
CP00215 N-α-Fmoc-L-Arginine 396.5 Inquiry
CP00216 N-α-Fmoc-N-ω-,N-ω′-di-allyloxycarbonyl-D-arginine 564.7 Inquiry

With the development of biotechnology, peptides have become more and more useful in the field of biomedicine. Protected amino acids are the most basic raw materials for solid-phase synthesis of peptides. Amino acids all contain α-amino and carboxyl groups. Some of the 20 amino acids also contain side-chain active groups, such as hydroxyl, amino, guanidine and heterocyclic groups. Different amino acids need their own protecting groups, and with the different types of synthetic peptides, the selected protecting group schemes are also different. Both the amino group and the side chain active group need to be protected in the peptide reaction. After the peptide is synthesized, the protective group is removed, otherwise the misconnection of amino acids and many side reactions will occur.

Classification of protected amino acids

Protected amino acids are generally divided into single-protected amino acids and double-protected amino acids. Single-protected amino acids refer to protected amino acids that only protect α-amino groups; double-protected amino acids refer to amino acids that require protection of side chain active groups in addition to α-amino groups.

Protection of amino groups

It can be divided into three main categories: alkoxycarbonyl, acyl and alkyl. Among them, Fooc protection in alkoxy groups is more common. Under weak alkaline conditions such as sodium carbonate or sodium bicarbonate, Fmoc-Cl or Fmoc-OSu is generally used to introduce Fmoc protecting groups. Compared with Fmoc-Cl, Fmoc-OSu is easier to control the reaction conditions and has fewer side reactions. Under acidic conditions, the Fmoc protecting group is particularly stable, but it is very sensitive to alkaline conditions, so it is usually used together with the acid-sensitive protecting group Boc or Z to protect amino acids containing active side chain groups.

Protection of side chain active groups

The active side chains of amino acids mainly include: hydroxyl, thiol, carboxyl, amino, sarcosyl, imidazole, amide, indole and thioether groups. When synthesizing peptides, these active groups are generally protected first, and then the peptide reaction is carried out to avoid some side reactions. For example, side chain amino groups must be protected during peptide synthesis, such as lysine. Different from the α-amino protecting group, the side chain amino protecting group must be selective, and it will not be affected when the other protecting groups are removed, and then removed after the peptide is synthesized. The earliest protecting group is p-toluenesulfonyl (Tos), which has good stability and can only be removed by Na/liquid ammonia treatment. Lysine first forms a ketone complex, and then reacts with Tos-Cl under weakly alkaline conditions to selectively protect the side chain amino group and then remove copper. Using Lys (Tos), people have successfully synthesized peptides and proteins such as oxytocin, vasopressin and insulin.

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Customer Support & Price Inquiry

Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!

  st-Ht31, a protein kinase A (PKA)-anchoring inhibitor, greatly induces robust cholesterol or phospholipid effl ...

 Protirelin is also known as thyrotropin releasing hormone (TRH), a peptide hormone secreted by the hypothalamus. ...

Brief information of orexin peptide The past several years have provided important insights into the physiological significan ...

Glucagon-like peptide-1 (GLP-1) and glucose-depended insulinotropic polypeptide (GIP) are the two peptides that have been con ...

 TC 14012 is a serum-stable derivative of the peptidomimetic T140, which is a cyclic peptide with the structure o ...

Quick Inquiry
×
Contact Us

USA

Address:

Tel: |

Email:

Germany

Address:

Copyright © 2024 Creative Peptides. All rights reserved.