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|CAT#||Product Name||M.W||Molecular Formula||Inquiry|
|C08216||Tyrosinase (206-214), T9206||1186.4||Inquiry|
|M04012||(Val438)-Tyrosinase (432-444) (human)||1500.54||Inquiry|
|R1116||[Asp371]-Tyrosinase (369-377), human||1031.16||C₄₂H₆₆N₁₀O₁₆S₂||Inquiry|
|T14004||Tyrosinase (192-200) (human, mouse)||1180.29||C54H77N13O17||Inquiry|
|T14005||Tyrosinase (206-214) (human)||1186.44||C61H83N15O10||Inquiry|
|T14006||Tyrosinase (243-251) (human)||1089.20||C44H68N10O18S2||Inquiry|
Tyrosinase is an oxidase and a rate-limiting enzyme that regulates melanin production. The enzyme is involved in two reactions of melanin synthesis: the first step is the hydroxylation of monophenol to diphenol, and the second step is the oxidation of catechol to o-diquinone. O-diquinone becomes melanin after a few more steps of reaction. Tyrosinase is a ketone-containing enzyme found in plant and animal tissues that catalyzes the production of melanin oxidized by tyrosine and other pigments, such as peeling or slicing potatoes exposed to the air. Tyrosinase is found in melanosomes of skin melanocytes. In the human genome, tyrosinase is encoded by the TYR gene.
In humans, the tyrosinase enzyme is encoded by the TYR gene. Tyrosinase is one of the key enzymes in mammalian melanin synthesis. Anti-tyrosinase has been found to be quite specific for melanin lesions such as malignant melanoma and melanin neurofibroma. At present, many tyrosine kinase inhibitors have been developed as antitumor drugs and white blood cell inhibitors. For example, Imatinib is used to treat chronic myeloid leukemia; Sunitinib, developed using early research on VEGF receptors, is also used to inhibit FGF, PDGF, VEGF, and other proteins.