Based on Creative Peptides Design PlatformTM (CPDP), we have constructed a total peptide library, which is a "new seed bank" for new drug research and development in the world, to fill the gap in peptide library construction technology at home and abroad.
The total peptide library is a collection of a large number of small peptide of specific length and different sequences, which includes the permutation and combination of various amino acid sequences in the short peptide of this length. The general synthetic peptide library uses 20 kinds of natural amino acids as building units, and the size of the library capacity is determined by the number of amino acids (n) that constitute a peptide of a specific length, which can be simply calculated as 20n. For example, to construct a dipeptide library, there are 202 (400=4×102) combinations, the tripeptide library has 203 (8,000=8×103) combinations, and so on. Therefore, the larger library capacity complicates the synthesis of peptide drugs and becomes a bottleneck in the development of peptide drugs.
Creative Peptides Design PlatformTM (CPDP) has developed peptide information compression technology, which uses bioinformatics methods to compress peptide information, which can integrate the information of multiple peptide into one peptide, so as to contain a large amount of peptide information in a relatively small storage volume. It opens up a new way to research and develop peptide drugs. Based on this technology, we have constructed a total peptide library, containing nearly 500 million different peptide sequence information in a library of approximately 80,000 peptides, which will increase the screening efficiency by approximately 6,000 times.
A total peptide library is a collection of peptides of varying sequences and lengths, created by combining natural amino acids. The library is constructed using bioinformatics methods and peptide information compression technology to store large amounts of peptide data in a compact format, enabling efficient screening and discovery.
The CPDP leverages peptide information compression technology to integrate multiple peptide sequences into a single, efficient format. This reduces the size of the library while maintaining the diversity of peptide sequences, resulting in faster and more effective screening.
The total peptide library is primarily used in peptide drug screening, antimicrobial peptide screening, cosmetic peptide screening, and peptide antibiotic screening. It accelerates the discovery of bioactive peptides by providing a broad range of sequences for evaluation.
The library's compression technology increases its screening efficiency by approximately 6,000 times, allowing for the evaluation of nearly 500 million peptide sequences in a library of just 80,000 peptides. This significantly speeds up the discovery process compared to traditional methods.
The total peptide library is characterized by its integrity, sequence diversity, and higher stability due to the peptide bond structure. Additionally, it has a low construction cost and short development cycle, making it a more cost-effective solution for peptide discovery.
The diverse peptide sequences in the library allow researchers to explore a wide variety of peptide properties, increasing the chances of discovering peptides with high specificity and efficacy for different biological targets. This broadens the scope of drug development possibilities.
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