Amino Acid Modifications

Protecting Group Modifications: We offer a variety of amino acid protecting group modifications, such as amino group protection (Fmoc, Boc, etc.) and carboxyl group protection (esterification, amidation, etc.), ensuring the stability and controllability of amino acids during synthesis, facilitating subsequent synthesis and purification operations. This service is suitable for applications in peptide synthesis and drug synthesis intermediates.

Acylation Modifications: Acylation reactions are carried out on amino acids' amino, hydroxyl, and other functional groups, introducing acyl groups of varying lengths and properties. This alters the amino acids' lipophilicity, solubility, and biological activity, and can be used to synthesize amino acid derivatives with specific biological functions, such as antimicrobial and antiviral peptides.

Alkylation Modifications: Amino acids are reacted with various alkyl reagents, such as methylation, ethylation, etc., to adjust the stereochemical properties and electronic effects of the amino acids. This affects their interactions with other molecules and provides molecular tools for studies on protein folding, conformational changes, and more. It is also used in the development of novel drug carriers and biomaterials.

Glycosylation Modifications: Sugar groups are attached to specific positions on the amino acids, simulating the glycan structures of natural glycoproteins. This modification allows for the synthesis of bioactive glycopeptides, useful in studying glycoprotein interactions, cell signaling processes, and the development of drugs for cancer, inflammation, and more.

Phosphorylation Modifications: Phosphoryl groups are precisely introduced onto the serine, threonine, or tyrosine residues of amino acids, simulating the phosphorylation status of proteins. This modification is critical for studying the mechanisms of protein kinases, phosphatases, and cell signal transduction pathways, and can be applied in the development of diagnostic reagents and therapeutic drugs.

Special Functional Group Modifications: Based on specific client needs, we design and synthesize amino acid modification products containing special functional groups (such as biotin, fluorescent groups, affinity tags, etc.). These modified amino acids can be used for biomolecule labeling, tracking, and purification studies, meeting personalized requirements for research and industrial production.

Amino Acid Molecular Conjugation Modifications: Amino acids are conjugated with other small molecules, macromolecules, or nanomaterials to develop composite materials with multifunctional properties. These materials, such as scaffolds for tissue engineering or drug release carriers in biomedical fields, can be customized based on client project requirements.

Amino Acid Structural Modification: Modifications are made to the side chains or backbone structures of amino acids to alter their physicochemical properties and biological activity. This supports the development of novel amino acid analogs and derivatives, assisting in drug development and innovation in new materials.

Enzymatic Modifications: Specific enzymes are used to catalyze reactions between amino acids and other molecules, such as enzymatic amino group transfer, acyl group transfer, etc. This enables efficient, stereoselective amino acid modifications with mild reaction conditions and environmental friendliness. These modifications are suitable for large-scale production of bioactive amino acid derivatives, and are applied in food, pharmaceutical, and biotechnology fields.

Bioconjugation Modifications: Through biocompatible chemical reactions, amino acids are conjugated with biomolecules (such as proteins, peptides, nucleic acids, etc.), forming biohybrids with synergistic effects. These conjugates are used to create novel biosensors, targeted drug delivery systems, and enhance stability and functionality within biological systems.