At Creative Peptides, all peptides undergo comprehensive quality management testing to meet routine applications, including MS and HPLC analysis throughout the peptide synthesis and purification process.
But biological analysis may be required for peptides used in certain types of essays. Creative Peptides provides various peptide bioanalysis services to support many different applications.
Endotoxin (also known as bacterial pyrogen, lipopolysaccharide (LPS)) is the main contaminant found in commercially available proteins or biologically active substances, which can cause severe reactions in humans and animals, like stimulate the mammalian immune system, reduce the viability of tissue culture cells, and inhibit transfection efficiency in vitro. And they are maintaining high toxicity even at low concentrations. Therefore, it must be removed before introducing the biological sample.
To enhance your experimental results, Creative Peptides now offers guaranteed endotoxin testing and removal services to reduce endotoxin levels to ≤0.01 EU/μg, which is ideal for most cell assays.
Reliable sterility testing and the development or validation of product-specific methods are key steps in the drug development process. If the peptide is intended for cell assays or the development of cell and immunotherapies or vaccines, sterility is important.
Creative Peptides offers reliable sterility testing methods, which is compliant to USP, EU, and JP Pharmacopoeias Compliant. In short, it includes
> Dissolve the lyophilized peptide in water
> The samples are incubated in two types of media to facilitate simultaneous detection of aerobic and anaerobic microorganisms.
The cytotoxicity test is an in vitro assay used to evaluate the possibility of a test article causing cell death or inhibiting cell growth. Cause certain counterions or residual solvents can show cytotoxicity, peptide samples should be tested for cytotoxicity before used in cell assays or other biological systems.
Creative Peptides provides comprehensive in vitro peptide cytotoxicity testing services, to assess peptides safety with reliable multiple toxicity test models to provide fast and cost-effective screening solutions.
Products used in the pharmaceutical, medical, cosmetics, food or beverages field need to control microbial levels during processing and handling. Creative Peptides' rapid microbial detection solution for bioburden testing effectively solves the contamination problems that peptides may encounter before use, through including testing the total aerobic microorganism count (TAMC) and the total number of yeast and mold (TYMC).
Creative Peptides offers a comprehensive range of biological testing services, including bacterial endotoxin testing and removal, peptide sterility testing, cell toxicity testing, and bioburden determination. These services are essential for ensuring the safety and effectiveness of peptides used in various biological applications.
Endotoxins, found in biologically active substances like proteins, can cause severe reactions, including immune system stimulation and cell culture toxicity. Our endotoxin testing and removal service reduces endotoxin levels to ≤0.01 EU/μg, ensuring that peptides are safe for use in cell assays and other biological experiments.
We perform sterility testing by dissolving lyophilized peptides in water and incubating the samples in two types of media for simultaneous detection of both aerobic and anaerobic microorganisms. Our sterility testing methods comply with USP, EU, and JP pharmacopoeia standards, ensuring the safety of peptides for use in cell-based assays and therapies.
Cell toxicity testing is crucial for evaluating whether a peptide could cause cell death or inhibit cell growth. It is an essential step before using peptides in cell assays or therapeutic applications. We provide comprehensive in vitro cytotoxicity testing services to assess the safety of peptides using multiple toxicity models.
Bioburden testing measures the microbial contamination of peptides, particularly in pharmaceutical, medical, and food products. We offer rapid microbial detection solutions to test for total aerobic microorganisms (TAMC) and yeast and mold (TYMC), ensuring peptides are free from harmful contaminants before use in production or research.
Yes, we offer customized biological testing services tailored to your specific research or industrial needs. Whether you require specific sterility testing, endotoxin removal, or toxicity assessments, we can work with you to ensure that our services meet your exact requirements.
Our testing methods are designed to meet rigorous industry standards, such as USP, EU, and JP pharmacopoeia guidelines. We use advanced techniques and technologies to ensure the accuracy, reproducibility, and reliability of all biological testing results, providing you with the data needed for successful peptide applications.
