Biological Testing

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

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At Creative Peptides, all peptides undergo comprehensive quality management testing to meet routine applications, including MS and HPLC analysis throughout the peptide synthesis and purification process.

But biological analysis may be required for peptides used in certain types of essays. Creative Peptides provides various peptide bioanalysis services to support many different applications.

Overview of our different type of biological testing

  • Bacterial Endotoxin Testing and Removal

Endotoxin (also known as bacterial pyrogen, lipopolysaccharide (LPS)) is the main contaminant found in commercially available proteins or biologically active substances, which can cause severe reactions in humans and animals, like stimulate the mammalian immune system, reduce the viability of tissue culture cells, and inhibit transfection efficiency in vitro. And they are maintaining high toxicity even at low concentrations. Therefore, it must be removed before introducing the biological sample.

To enhance your experimental results, Creative Peptides now offers guaranteed endotoxin testing and removal services to reduce endotoxin levels to ≤0.01 EU/μg, which is ideal for most cell assays.

  • Peptide Sterility Testing

Reliable sterility testing and the development or validation of product-specific methods are key steps in the drug development process. If the peptide is intended for cell assays or the development of cell and immunotherapies or vaccines, sterility is important.

Creative Peptides offers reliable sterility testing methods, which is compliant to USP, EU, and JP Pharmacopoeias Compliant. In short, it includes

> Dissolve the lyophilized peptide in water
> The samples are incubated in two types of media to facilitate simultaneous detection of aerobic and anaerobic microorganisms.

  • Cell Toxicity Testing

The cytotoxicity test is an in vitro assay used to evaluate the possibility of a test article causing cell death or inhibiting cell growth. Cause certain counterions or residual solvents can show cytotoxicity, peptide samples should be tested for cytotoxicity before used in cell assays or other biological systems.

Creative Peptides provides comprehensive in vitro peptide cytotoxicity testing services, to assess peptides safety with reliable multiple toxicity test models to provide fast and cost-effective screening solutions.

  • Bioburden Determination

Products used in the pharmaceutical, medical, cosmetics, food or beverages field need to control microbial levels during processing and handling. Creative Peptides' rapid microbial detection solution for bioburden testing effectively solves the contamination problems that peptides may encounter before use, through including testing the total aerobic microorganism count (TAMC) and the total number of yeast and mold (TYMC).

Recommended for peptides used in

  • Cellular assays
  • Immunotherapy
  • Active pharmaceutical ingredients (APIs)

The Process

Biological Testing

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
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