* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
Cat. # | Product name | CAS No. | Price |
---|---|---|---|
M34140617H | DOTA | 60239-18-1 | Inquiry |
M34140618H | DOTAEt | 137076-50-7 | Inquiry |
M34140620H | DOTA-Ubiquicidin (29-41) acetate | N/A | Inquiry |
M34140622H | DOTATOC | 204318-14-9 | Inquiry |
M34140623H | Ga-DOTA-TOC acetate | 293295-70-2 | Inquiry |
M34140624H | Y-DOTA-TOC | 293295-66-6 | Inquiry |
M34140625H | Lu-DOTA-TOC | 321835-55-6 | Inquiry |
M34140626H | DOTA-NOC acetate | 619300-53-7 | Inquiry |
M34140628H | DOTA-bombesin (1-14) | 593287-40-2 | Inquiry |
M34140629H | Ga-DOTA-NOC | 1027785-95-0 | Inquiry |
M34140643H | DOTA-Lanreotide acetate | 213187-44-1 | Inquiry |
M34140645H | DOTA-NAPamide trifluoroacetate | 935886-72-9 | Inquiry |
M34140646H | DOTA-Sargastrin | N/A | Inquiry |
M34140649H | DOTA-cyclo(RGDfK) acetate | 909024-55-1 | Inquiry |
R1831 | DOTA-(Tyr3)-Octreotate | 177943-89-4 | Inquiry |
Peptide-based targeting vectors are becoming increasingly popular for diagnostic and therapeutic applications. They offer several advantages over antibodies including more favorable pharmacokinetics and better tumor penetration. Peptide sequences that are capable of binding to their target with affinities comparable to those of monoclonal antibodies can be generated by chemical or phage display libraries. Affinity selection of random phage display peptide libraries is a very powerful way of identifying novel targeting sequences for a receptor from billions of peptides.
Among many ligands, the macrocyclic 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) stands out, as it forms complexes with Ln(III) ions with extraordinary thermodynamic stability and kinetic inertness. It should be emphasized that DOTA complexes are significantly more inert kinetically than chelates of DTPA, and although both DOTA and DTPA complexes have been used as imaging agents and radiopharmaceuticals, DTPA complexes have been shown to dissociate and release metal under physiological conditions. This may not be of concern in the case of an MRI exam with Gd-DTPA when clearance of the contrast agent is rapid, but for targeted radiopharmaceutical applications, when the clearance of the complex is slow, DOTA and not DTPA should be the ligand of choice.
The DOTATOC for scanning
DOTA is an organic compound and commonly used as a complexing agent, which has been widely used as contrast agent for cancer treatments. It can also be linked to molecules that have affinity to various structures (e.g. somatostatin receptors on neuroendocrine tumours). The generated compounds may combine with a number of radioisotopes to be used in cancer therapy and diagnosis. Complexes of DOTA peptides, depending on the metal ion, have found applications in three major areas: magnetic resonance imaging [GdIII), Eu(III)], nuclear imaging [111In(III), 68Ga(III), 64/67Cu(II)], and therapeutic radiopharmaceuticals [90Y(III), 177Lu(III)].
For example, DOTA could act as a chelator for a radionuclide. (Tyr3)-octreotate, a derivative of octreotide, can bind to somatostatin receptors that are found on the cell surfaces of a number of neuroendocrine tumours. Therefore, DOTA-(Tyr3)-Octreotate is able to direct the radioactivity into the tumour.
For customized DOTA peptides please visit our Peptides-Metal Chelates Conjugation page.
Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!
Camstatin is a similar PEP-19 analogue with enhanced calmodulin binding and antagonism. It is a functional 25- ...
Purotoxin 1, a component from the venom of Geolycosa spiders, exerts selective inhibitory action on P2X3 recep ...
PAC-113, as well as a new type of Trp-rich peptide, is a 12 amino-acid fragment of the saliva protein histatin 5 ...
AdTx1, also called as ρ-Da1a, is a polypeptide of 65 amino acids stabilized by four disulfide bonds, which has a ...
Signal peptides stimulate matrix protein production in general and collagen synthesis in specific. They may be accomplished b ...