Edotreotide

Edotreotide is a chelated octreotide derivative with somatostatin activity. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of octreotide and chelated via dodecanetetraacetic acid (DOTA). Like octreotide, this edotreotide binds to somatostatin receptors (SSTRs), especially type 2, present on the cell membrane of many types of neuroendocrine tumors.

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CAT#10-101-210
Chemical Structure
CAS204318-14-9
Synonyms/AliasDOTA-[TYR3]-OCTREOTIDE;DOTATOC;DOTA-FCYWKTCT-OL (DISULFIDE BRIDGE: 2-7);DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7);[DOTA-DPHE1, TYR3]OCTREOTIDE;DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THREONINOL;EDOTREOTIDE;4,7,10-TRICARBOXYMETHYL-1,4,7,10-TETRAAZA-CYCLODODECAN-1-YL-ACETYL-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-L-THREONINOL, (DISULFIDE BOND)
M.F/FormulaC65H92N14O18S2(netpeptide)
M.W/Mr.1421.66
SequenceThree Letter Code: DOTA-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), cyclic disulfide
Biological ActivityEdotreotide is used in the Diagnosis and Staging of Tumors Expressing Somatostatin Receptors. It is an Indicator and Reagent.
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