Peptide antigen, namely, a peptide used to trigger animal's immune system to develop antibodies specific to that peptide. Nowadays, the use of synthetic peptide antigens as immunogens has markedly increased, and this technique is also widely applied for immune research such as tumor immunotherapy etc. Although many peptide sequences are immunogenic, not all of them are identically effective in generating antibodies when act against the target protein. Effective antibody generation depends on several factors that need to be considered at the very first stage of peptides designing.
Mimicking specific parts of the target protein, peptide antigens can provide much flexibility for scientific research. However, most of synthetic peptides are composed of 10AA -25AA, which are too short to generate a strong immune response without prior conjugation to a carrier protein such as Keyhole Limpet Hemocyanin (KLH), Ovalbumin (OVA) or Thyroglobulin (Tg). Creative peptides specialists can help with antigen design to maximize the chances that the peptide used as antigen can generate sufficient and effective antibody.
In recently years, there is an increasing attention focused on the function of glycopeptides. As we know, extracellular secreted proteins are often glycosylated, especially the extracellular segments. Glycoproteins are also the most important integral membrane proteins, and play a role in cell–cell interactions. With the increasing demand of antigen peptides, Creative Peptides is endeavor to support customers with superior antigen peptides services. Please kindly check below Fig. 2 for the glycosylation sites of Apolipoprotein J to generate mAbs as an example of our antigen peptides service.
Fig. 2 Example of our glycopeptides for generation antibody
Products of antigen peptides
Last but not least, Creative Peptides also provides remarkable one-step services from synthesis peptides to generation antibody. We are confident in applying our experience, industry and regulatory knowledge to design actual strategic packages pertinent to customers' project.
A peptide antigen is a short peptide used to stimulate an immune response in animals, leading to the production of antibodies specific to that peptide. This technique is widely used in immune research and immunotherapy.
Peptides alone, typically 10-25 amino acids in length, often lack sufficient immunogenicity. Conjugating them to carrier proteins like KLH or OVA enhances their ability to stimulate a stronger immune response and generate antibodies.
Glycopeptides are peptides that have glycosylation modifications. They are crucial for generating antibodies against glycoproteins, which play a key role in cell-cell interactions and are often involved in diseases such as cancer and autoimmune disorders.
We employ advanced strategies to design peptide antigens that mimic specific parts of the target protein. This maximizes the likelihood of generating effective antibodies for research and therapeutic applications.
We offer a wide range of peptide antigens, including those derived from infectious diseases, tumor-associated antigens, and control pools. These peptides can be used in various applications such as vaccine development and biomarker discovery.
Yes, we provide end-to-end services, from synthesizing the peptides to generating antibodies. Our expertise ensures high-quality results tailored to your research needs.
Peptide antigens derived from tumor-associated proteins can help develop targeted immune responses against cancer cells, playing a critical role in the development of personalized immunotherapies.
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