Creative Peptides is a well-known peptide company at home and abroad, which can provide various small-molecule and peptide coupling services. Creative Peptides has professional staff who can provide comprehensive product descriptions and quality inspection report electronic file packages to meet customers' various needs for Peptide-small-molecule Conjugation.
Peptide-small-molecule Conjugation can couple peptides with various small molecules (Fluorophores, chelating agents and therapeutics). In tumor treatment, peptides can avoid poor penetration, slow clearance, and immunogenicity of large molecular proteins. It has a strong advantage, and even has the tendency to replace traditional antibody diagnostic reagents. In terms of peptide probes, peptide-small-molecule conjugates have the characteristics of good selectivity, low immunogenicity, good biocompatibility, strong permeability and easy excretion. Peptide molecular probes are the main type of peptide-small-molecule conjugates. This method can achieve the rapid metabolism of tumor targeted molecular diagnosis.
Peptide-small-molecule conjugates as fluorescently labeled probes play an important role in tumorigenesis and development. The researchers successfully designed and screened a small molecule peptide probe AP2H with high affinity and high selectivity. The fluorescently labeled AP2H probe realizes the identification, localization and dynamic analysis of LAPTM4B protein in live liver cancer cells, demonstrating its advantages of good biocompatibility, strong penetration and low immunogenicity.
In addition, the researchers prepared a new type of water-soluble NIR-II fluorescent small molecule IRT, which was coupled with CP peptide by the click reaction for tail vein injection and live tumor imaging. The use of peptide molecular probes to achieve targeted diagnosis of tumors.
Generally, various imaging elements such as organic fluorophores, magnetic ion chelating agents, and radionuclides can be covalently bound to the peptide by modification or embedded in the peptide by physical methods.
Therefore, nanopeptide-small-molecule conjugates based on peptide self-assembly can be used for fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, computed tomography imaging and radiation imaging.
We have proven expertise in the conjugation of peptides to a wide variety of small molecules, which can be designed and manufactured using a wide variety of linkages.
Peptide-small-molecule conjugation involves linking peptides to small molecules like fluorophores, chelating agents, or therapeutic compounds. This method enhances the properties of peptides, such as penetration and specificity.
These conjugates offer high selectivity, low immunogenicity, and excellent biocompatibility. They enable targeted imaging, allowing real-time tumor localization and analysis.
These conjugates can be designed to target cancer cells specifically, enhancing therapeutic effects while reducing side effects. This approach improves drug delivery efficiency.
Peptides can be conjugated with small molecules like adrenergic agonists, mycotoxins, antibiotics, and steroid hormones. These molecules improve the peptide's functional capabilities.
Yes, they can be used for targeted research in epigenetics, offering precise targeting of specific proteins or cellular pathways involved in gene regulation.
These conjugates can be utilized in fluorescence imaging, photoacoustic imaging, MRI, and even radiation imaging. They enhance the resolution and accuracy of imaging technologies.
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