Peptide N-Terminal Modification
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Peptide N-Terminal Modification

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N-Terminal-Modification.pngAlthough many of the most widely recognized post-translational modifications are characteristic of secretory or cell-surface proteins, most proteins, whatever their ultimate cellular desination, undergo some modification. For proteins synthesized completely within the cytoplasm, the earliest and most widespread are removal or modification of the N-terminal residue. In many proteins the N-terminal α-ammonium group (PK=8) undergoes secondary modification.

N-terminal modification reduces overall solubility of the peptide by reducing its overall charges. However, the stability of the peptide could also be increased because N terminal modification generates a closer mimic of the native protein. Therefore, these modifications might increase the biological activity of a peptide and prevent degradation by enzymes.

Below is a list of our available N-terminal modifications (include but not limited to the following):

> 5-FAM/5-FAM-Ahx> Abz> Acetylation
> Acryl> Alloc> Benzoyl (Bz)
> Biotin/Biotin-Ahx> BOC> Benzyloxycarbonylation (CBZ)
> Chenodeoxycholic acid> Dansyl/Dansyl-Ahx> Decanoic acid
> D (+) Glucose> DNP> FITC/FITC-Ahx
> Fmoc> Formylation> Hexanoic acid
> Lauric acid> Lipoic acid> Maleimide
> 3-Mercaptopropyl (Mpa)> Myristoyl> Octanoic acid
> Palmitoyl> Pentinoic Acid> PEN
> Propiolic Acid> Pyroglutamyl (pGlu) (Pyr)> Stearic acid
> Succinylation> Tertbutoxycarbonyl (Boc)> TMR

Creative Peptides is specialized in the custom synthesis of N-terminal modification peptides, providing a confidential and efficient service at competitive prices. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. Typical delivery specifications include:

  1. HPLC chromatogram
  2. Mass spec analysis
  3. Synthesis report
  4. Certificate of Analyses

References:
[1] Dixon, H. B. F. (1984). N-terminal modification of proteins—a review. Journal of protein chemistry, 3(1), 99-108.
[2] Obermeyer, A. C., Jarman, J. B., & Francis, M. B. (2014). N-terminal modification of proteins with o-aminophenols. Journal of the American Chemical Society, 136(27), 9572-9579.
[3] Laurichesse, S., & Avérous, L. (2014). Chemical modification of lignins: Towards biobased polymers. Progress in Polymer Science, 39(7), 1266-1290.

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
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