IntraCellular Delivery System(ICDS™)
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IntraCellular Delivery System(ICDS™)

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Creative Peptides is now offering free sample of ICDSTM-NH2-kit with limited quantities. Please do not hesitate
to contact us at while stocks last.

Creative Peptides has launched a novel ICDSTM-NH2-kit. It could be used to facilitate the transfer of peptides or proteins as well as antibodies across cellular membranes in the cell-based assay.

Description:

Therapeutic protein drugs are an important class of medicines most in need of novel therapies. Recently approved recombinant protein therapeutics have been developed to treat a wide variety of clinical indications, including cancers, autoimmunity/inflammation, exposure to infectious agents, and genetic disorders. However, the failure of proteins to penetrate mammalian cells or target tumor cells restricts their value as therapeutic tools in a variety of diseases. Unlike small molecules, a peptide or a protein is normally difficult enter into intact cells due to the cell membrane's semipermeability nature.

Creative Peptides offer ICDSTM-NH2-kit containing good carriers that can easily cross cell membranes. ICDSTM-NH2-kit considered as useful tools to assist the transshipment of peptide or protein from outside to the inside of cells. It provides a convenient way to deliver your bioactive proteins into cells by conjugating them with ICDSTM peptides. This ICDSTM-NH2-kit can be used with a wide range of molecule up to 150kDa. In order to verify its effectiveness, Creative Peptides’ scientists have tested ICDSTM-NH2-kit using a wide variety type of cells, such as SkBr3, HEK293 and CHO, and nearly all of the tests have the positive results.

How does it work?

ICDS<sup>TM</sup> Service

ICDSTM-NH2-kit mainly composed of ICDSTM peptides and linker, can assemble your protein with ICDSTM peptides to form a conjugate which can flexible transfer across the cell membrane. ICDSTM-NH2-kit is highly and specifically adaptable to many possible applications, giving your research great advantages.

CAT#Product NameKit ContentsStorageProtocols
ICDS001ICDSTM-NH2-kitICDSTM peptides: 1 mg.
ICDSTM Linker: 2 mg.
Buffer: PBS solution (5 mL)
Filtration Tube: 2 tubes
4 ℃User Guide: ICDSTM-NH2-kit protocal

Protocol at a glance:
• Add ICDSTM linker solution to your protein sample and mix for 30 minutes and centrifuge for 10 minutes @ 10,000 g.
• Add PBS buffer and centrifuge for 10 minutes @ 10,000 g (2x).
• Add ICDSTM peptides for 2h at room temperature and centrifuge for 10 minutes @ 10,000 g.
• Move to a new filtration tube and add PBS buffer centrifuge for 10 minutes @ 10,000 g (2x).

Application:
• Protein/peptide-base vaccine
• Drug delivery
• Alteration of biological activity in cells/tissues

If you foresee a possible future use for your research in a clinical setting, we can help. Contact us at to customize your ICDSTM service today!

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
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