Fluorescence and Dye Labeling Peptides
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Fluorescence and Dye Labeling Peptides

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Fluorescent techniques have revolutionized biochemical research over the last 20 years. Because they have characteristics of high sensitivity, selectivity, fast response time, flexibility and experimental simplicity, the use of fluorescent techniques in biological research is very widespread. In many cases, biological sensors consist of fluorescent versions of a particular protein (Fig. 2).

There are different distances between different fluorophores that affect the fluorescent signal. An interesting strategy for the synthesis of sensors involves the application to peptides of the molecular beacon concept that was developed in the field of nucleic acid sensors. The development of peptide-based sensors over the last two decades has been spectacular: FRET effects or environment sensitive fluorophores provide reliable design strategies that can be safely implemented to study virtually any biological interaction with minimal effort. The large number of commercially available fluorophores, many of them in the form of activated species ready for derivatization, has simplified the synthetic effort required to obtain the modified peptides and increased the flexibility of the designs. Given the increasing interest in the development of chemical tools for biological research, the importance of these peptide probes is only expected to grow.

Fig. 2. Advantages and limitations of different fluorescent probes

Available fluorescence and dye labeling peptides services

Creative Peptides provides available fluorescence and dye labeling peptides services to meet your custom peptide need. Each fluorescence and dye labeled peptide delivered as a lyophilized powder in foil covered tube. These peptide modifications can be used to create synthetic peptide with the exact conformation of characteristics needed for specific applications.

Below is a list of our available modifications (include but not limited to the following):

> Fluorescein Isothiocyanate> Anthranilyl> 5/6-Carboxyfluorescein
> Carboxytetramethyl Rhodamine> Dansyl> EDANS
> Cy3/5> Mca> Rhodamine B
> Cyanines> ATTO dyes> Alexa dyes
> Abz – Dnp> EDANS – Dabcyl> Mca – Dnp
> Tryptophan – Dnp> FAM – Dabcyl

Creative Peptides is specialized in the custom synthesis of fluorescence and dye labeling peptides, providing a confidential and efficient service at competitive prices. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. Typical delivery specifications include:

  1. HPLC chromatogram
  2. Mass spec analysis
  3. Synthesis report
  4. Certificate of Analyses

References:
[1] Demeter, O., Kormos, A., Koehler, C., Mező, G., Németh, K., Kozma, E., ... & Kele, P. (2017). Bisazide Cyanine Dyes as Fluorogenic Probes for Bis-Cyclooctynylated Peptide Tags and as Fluorogenic Cross-Linkers of Cyclooctynylated Proteins. Bioconjugate chemistry, 28(5), 1552-1559.
[2] Vasconcelos, L., Lehto, T., Madani, F., Radoi, V., Hällbrink, M., Vukojević, V., & Langel, Ü. (2018). Simultaneous membrane interaction of amphipathic peptide monomers, self-aggregates and cargo complexes detected by fluorescence correlation spectroscopy. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1860(2), 491-504.
[3] Pazos, E., Vazquez, O., Mascarenas, J. L., & Vazquez, M. E. (2009). Peptide-based fluorescent biosensors. Chemical Society Reviews, 38, 3348-3359.

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
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