Checkpoint Inhibitors

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

Browse products name by alphabetical order:

C H O
CAT# Product Name M.W Molecular Formula Inquiry
C14019 CEF20, Cytomegalovirus, CMV pp65 (495-503) 943.2 Inquiry
C33011 Cytochrome C (88-104) (domestic pigeon) 1890.21 Inquiry
CR00001 CBP501 Affinity Peptide 1662.89 C₆₈H₁₁₉N₂₁O₂₅S Inquiry
CR00002 HIV-1 gag Protein p17 (76-84) 981.11 C₄₄H₇₂N₁₀O₁₅ Inquiry
R1275 CEF1, Influenza Matrix Protein M1 58-66 966.17 C₄₉H₇₅N₉O₁₁ Inquiry
R1856 OVA (323-339) 1773.9 C74H120N26O25 Inquiry

An important part of the immune system is its ability to distinguish between normal cells in the body and cells that it considers to be "foreign". This allows the immune system to attack foreign cells away from normal cells. To do this, it uses "checkpoints"-some molecules on immune cells that need to be activated (or inactivated) to initiate an immune response. Checkpoint inhibitors are also described as a monoclonal antibody or targeted therapy.

Examples of Checkpoint Inhibitors

PD-1 is a checkpoint protein on immune cells called T cells. It usually acts as a "shutdown switch" to help prevent T cells from attacking other cells in the body. It does this when it attaches to PD-L1, a protein on some normal and cancer cells. When PD-1 binds to PD-L1, it basically tells T cells to stay away from another cell. Some cancer cells contain large amounts of PD-L1, which helps them escape immune attacks. Monoclonal antibodies against PD-1 or PD-L1 can block this binding and enhance the immune response to cancer cells. These drugs show great potential in the treatment of certain cancers.

CTLA-4 is another protein on some T cells that acts as a "shutdown switch" to maintain control of the immune system. CTLA-4 can suspend the response of activated T cells to (T cell response) and mediate the inhibitory function of Treg. Using a mouse model of bladder cancer, the researchers found that local injection of low doses of anti-CTLA-4 antibody into the tumor area had the same ability to inhibit the tumor as it did when the antibody was transported in the blood. At the same time, the level of circulating antibody is also low, that is, the effect of local injection of anti-CTLA-4 is the same as that of anti-CTLA-4 antibody injected in blood. At the same time, the level of antibody in circulation is also low, suggesting that local application of anti-CTLA-4 treatment can reduce adverse reactions.

Conclusion

The clinical success of immunosuppressive agents has brought new life to the immunotherapy of cancer. What we need to do in the future is how to improve the efficiency of immune checkpoint blocking and immune checkpoint inhibitor combination therapy to enable patients who cannot be treated with single blocker to obtain a lasting anti-tumor response. How to develop an effective combination of immune checkpoint blocking therapy to increase efficacy and reduce side effects. Tumors use a variety of means to escape immune elimination, so it is necessary to better understand the immunosuppression of tumor microenvironment.

References

  1. Mahoney, K. M., Freeman, G. J., & McDermott, D. F. (2015). The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma. Clinical therapeutics, 37(4), 764-782.
  2. Hui, E. (2019). Immune checkpoint inhibitors. J Cell Biol, 218(3), 740-741.

Resource

Creative Peptides is a custom lab chemical supplier that provides a wide range of peptides for the pharmaceutical and biotechnology industries.

Learn More

BA 1, a potent BRS-3 agonist

 BA 1 (DTyr-Gln-Trp-Ala-Val- Ala-His-Phe-Nle-NH2) is a potent BRS-3 agonist (IC50 = 2.52 nM) and a NMBR and GRPR ...

Function of dynorphin A (1-13) in ischemic brain injury

 Dynorphin A (1-13) [Dyn-A (1-13)] is a short-chain polypeptide containing 13 amino acids and having extensive bi ...

Function of D15 As An Endocytosis Inhibitor

  The endocytosis of AMPA receptors (AMPARs) requires the GTPase activity of dynamin. Since it is now established ...

Obtustatin: a potent selective α1β1 inhibitor

 Obtustatin isolated from the venom of the Vipera lebetina obtusa viper is a highly potent integrin α1β1 inhibito ...

Function of thymosin β15 in metastatic prostate cancer diagnosis

 As a small actin-binding protein upregulated in highly metastatic prostate cancer cells, thymosin β15 (Tβ15) has ...

Contact Us

Address:

Tel: |

Email:

Copyright © 2022 Creative Peptides. All rights reserved.