Custom Conjugation Service

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Custom Conjugation ServiceLeveraging our expertise and knowledge in peptides manufacturing, Creative Peptides provides convenient multiple types of peptide conjugation services to meet the needs of different projects, including activating immune responses, obtaining higher stability and cell penetration.

What is Peptide Conjugation?

Peptides are short chains of amino acids that play essential roles in biological processes and have emerged as versatile molecules for various applications. However, the inherent limitations of peptides, such as poor stability and rapid degradation, often hinder their practical utility. Peptide conjugation, through the attachment of functional groups or molecules, offers a solution to enhance the properties and expand the applications of peptides. Peptide conjugation refers to the process of covalently linking a peptide to another molecule or entity, such as a protein, drug, or fluorescent probe. This can be achieved through a variety of chemical reactions, including amide bond formation, thiol-maleimide coupling, and click chemistry.

General approach to peptide therapeuticsGeneral approach to peptide therapeutics (VM Ahrens, et, al. 2012)

Advantages of Peptide Conjugation

  • Increased specificity
  • Enhanced stability
  • Targeted delivery
  • Versatility

Application of Peptide Conjugation

  • Improving the efficacy and specificity of drugs
  • Peptide-Based Imaging Probes

Creating imaging probes for a variety of applications, such as in vivo imaging, fluorescent microscopy, and magnetic resonance imaging (MRI). Peptides can be conjugated to imaging agents, such as fluorophores, radiolabels, or magnetic nanoparticles, to develop highly specific imaging probes.

  • Diagnostic Assays

Developing diagnostic assays for detecting specific biomarkers or diseases. Peptide conjugation can enable the detection and imaging of specific targets with high sensitivity and specificity.

  • Modifying the properties of biomaterials for tissue engineering or drug delivery applications.
  • Developing peptide-based vaccines
  • Developing biosensors for detecting analytes in complex biological samples.

Peptides can be immobilized onto sensor surfaces, either directly or through conjugation with recognition elements (e.g., antibodies, aptamers), to enable specific and sensitive detection. Peptide-based biosensors offer advantages such as rapid response, high selectivity, and potential for miniaturization, making them valuable tools in clinical diagnostics, environmental monitoring, and food safety.

  • Drug Delivery Systems

By improving the pharmacokinetics, stability, and targeting capabilities of therapeutic agents.

  • Prodrug Strategies

Peptide conjugation can be employed to design prodrugs, which are inactive or less active forms of drugs that undergo enzymatic or chemical activation at the target site.

  • Materials Science

Peptide conjugation has opened up new possibilities in materials science, enabling the fabrication of functional materials with diverse applications.

Available Peptide Conjugation Services

Our ServicesDescriptionPrice

Peptide-oligonucleotide Conjugation

Conjugated oligonucleotides and peptides by covalent attachment can enhance the function of the oligonucleotide. Studies have shown that peptide and oligonucleotide conjugates have stronger target cell penetration and higher cell absorption efficiency than unmodified oligonucleotides.Inquiry

Peptide-siRNA Conjugation

Peptide-siRNA Conjugation technology is to use peptides as a carrier of nucleic acids to bring short siRNA into the body, exert its gene silencing effect, and specifically silence the expression of target genes to achieve therapeutic purposes.Inquiry

Peptide-DNA Conjugation

Peptide-DNA conjugates are molecular chimeras composed of nucleic acid moieties covalently attached to polypeptide parts and are used in a variety of applications such as therapy and nanotechnology. A common strategy is to combine a cell-penetrating carrier peptide with a phosphorosulfate DNA chain that enhances the nuclease attack ability.Inquiry

Peptide-RNA Conjugation

Peptide-RNA conjugate is considered a useful drug because its stability is much better than RNA. Methods for preparing peptide-RNA conjugates include: post-synthesis coupling method (or post-assembly coupling method and fragment coupling method), fully stepwise synthesis method (or online solid-phase synthesis method), natural coupling method and template orientation coupling method.Inquiry

ASO Peptide Conjugate

An ASO peptide conjugate is a molecule that consists of an antisense oligonucleotide (ASO) linked to a peptide. Antisense oligonucleotides (ASOs) are short, synthetic pieces of DNA or RNA that are designed to target specific genes and inhibit their expression. Peptides, on the other hand, are short chains of amino acids that can have a variety of functions, such as binding to receptors or penetrating cell membranes.Inquiry

GalNac Peptide Conjugate

The GalNAc peptide conjugate molecule is one of the most fascinating types of therapeutic entities in the domain of pharmacology. It consists of a peptide or protein drug that is intricately connected to a GalNAc (N-acetylgalactosamine) molecule, forming a remarkable hybrid structure. This complex architecture aims to enhance the selectivity and transport of the therapeutic agent to desired cellular and tissue sites while simultaneously mitigating the danger of non-specific, off-target effects.Inquiry

Peptide Nucleic Acid Conjugate

Peptide nucleic acid (PNA) is a DNA mimic with a pseudopeptide backbone composed of N-(2-amino-ethyl)glycine (aeg) units to which the nucleobases are linked through methylene carbonyl linkers. Despite the radical difference in the chemical composition of the backbone, PNA not only retains but also improves the hybridisation characteristics of DNA and RNA.Inquiry

Peptide-small-molecule Conjugation

Peptide can be coupled with various small molecules, such as fluorophores, chelating agents, and therapeutics. Peptide-small-molecule conjugates have the characteristics of good selectivity, low immunogenicity, good biocompatibility, strong permeability, and easy excretion, which can be used in tumor-targeted molecular diagnosis.Inquiry

Gold/Silver Nanoparticles Conjugation

Scientific research on nanoparticles (NPs) is intense as they have many potential applications in medicine, physics, optics, and electronics. NPs can be used to deliver a cargo, such as an anticancer drug, or a cohort of radionuclide atoms to a targeted region of the body.Inquiry

Peptide-Antibody Conjugation

Peptide-Antibody Conjugation technology can further improve the accuracy of peptide delivery based on the guidance of antibodies and facilitates the delivery of conjugate aprotinin-derived peptides across the blood-brain barrier.Inquiry

Peptides-Carraier Protein Conjugation

Allow the induction of a B-cell response to the entire immunogen, including the peptide. New synthetic peptides thus offer promise as vaccines.Inquiry

Peptide-enzyme Conjugation

Peptide enzyme conjugates can detect immune complexes by visual or spectrophotometry as sensitive probes. Enzyme labels provide the best overall performance, high sensitivity, low background, and can achieve fast detection.Inquiry

Peptides-Metal Chelates Conjugation

Peptides-Metal Chelates Conjugation is a kind of compound with cyclic structure which is formed by chelation reaction between peptide and metal ions. It can improve the bioavailability of metal ions by means of the absorption mechanism of peptides in the body, and has physiological and biochemical characteristics that inorganic metal ions do not have.Inquiry

Peptides-Fatty Acids Conjugation

Peptides-Fatty acids Conjugation is obtained by fatty acid modification of the main chain structure or contralateral chain group of polypeptide drugs, which can also be used for a number of different applications, for example, improving drug solubility and absorption, prolonging the half-life of peptide drugs in the circulation and enhancing plasma albumin binding rate.Inquiry

NHS-Activated Peptide Conjugation Magnetic Beads

NHS-Activated Peptide Conjugation Magnetic Beads, also called immunomagnetic microspheres, is a small spherical particle with superparamagnetic and protective shell, which is mainly used in the field of separation and purification, such as protein separation and purification, antibody separation and purification.Inquiry

Peptides-Imaging Agents Conjugation

Peptide-imaging agent conjugation is a molecular probe that can be used for organ, tissue, or molecular imaging. After peptide-imaging agent conjugation is introduced into the body, it can concentrate in the target organ or tissue, detect the radiation emitted by the imaging instrument, and obtain the distribution image of the drug in the body, which can be used to diagnose various diseases.Inquiry

Peptide-Polymer Conjugation

Peptide-polymer conjugation is a new class of soft substances composed of natural and synthetic components.Inquiry

Main Advantages

  • Highly stable conjugate
  • Muti-type conjugations available

Peptide conjugation through N-terminal amine, C-terminal acid, Cys thiol, or other functional groups are available.

  • Save time and cost
  • Purification

Depending on the type of molecule used for conjugation, normally low molecular weight contaminants will be eliminated by SEC chromatography or HPLC.

  • Quality Control

Gel electrophoresis, MALDI MS (except for KLH) or other appropriate analysis.

Creative Peptides has developed a reliable method for custom peptide conjugation, and we will provide custom peptide conjugation services to global customers with excellent technology. Every step of peptide synthesis is subject to Creative Peptides' stringent quality control. The experienced experts and advanced instruments in the Creative Peptides can meet all your needs for peptides conjugation. We will provide you with a full range of synthesis and modification services. As a partner in your research, we look forward to deeper cooperation. Please contact us!

References

  1. Schmitz, M., Kuhlmann, M., Reimann, O., Hackenberger, C. P., & Groll, J. Side-chain cysteine-functionalized poly (2-oxazoline) s for multiple peptide conjugation by native chemical ligation. Biomacromolecules. 2015; 16(4):1088-1094.
  2. Zhao, M., Kircher, M. F., Josephson, L., & Weissleder, R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjugate Chemistry. 2002; 13(4): 840-844.
  3. Stetsenko, D. A., & Gait, M. J. Efficient conjugation of peptides to oligonucleotides by "native ligation". The Journal of Organic Chemistry. 2000; 65(16):4900-4908.
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