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Custom Conjugation Service
Normally, an antigen is a large, complex molecule with a molecular weight greater than 10kDa and as such, is able to promote a good immune response and induce high levels of specific antibody. Peptides are very small molecules, typically 1000-2000 Daltons, which even when emulsified in adjuvant are able to elicit only a very poor immune response. Such small molecules are called haptens. As a result, it is necessary to conjugate the peptide to a larger carrier molecul, such as Protein, Oligonucleotide, Enzyme, Metal Chelates, etc.
Available Peptide Conjugation Services
Scientific research on nanoparticles (NPs) is intense as they have many potential applications in medicine, physics, optics, and electronics. NPs can be used to deliver a cargo, such as an anticancer drug, or a cohort of radionuclide atoms to a targeted region of the body.
Coupling peptide to a large carrier protein containing T-cell epitopes allows the induction of a B-cell response to the entire immunogen, including the peptide. New synthetic peptides thus offer promise as vaccines.
Conjugated oligonucleotides and peptides by covalent attachment can enhance the function of the oligonucleotide. Studies have shown that peptide and oligonucleotide conjugates have stronger target cell penetration and higher cell absorption efficiency than unmodified oligonucleotides.
Peptide enzyme conjugates can detect immune complexes by visual or spectrophotometry as sensitive probes. Enzyme labels provide the best overall performance, high sensitivity, low background, and can achieve fast detection.
Peptides-Metal Chelates Conjugation is a kind of compound with cyclic structure which is formed by chelation reaction between peptide and metal ions. It can improve the bioavailability of metal ions by means of the absorption mechanism of peptides in the body, and has physiological and biochemical characteristics that inorganic metal ions do not have.
Peptides-Fatty acids Conjugation is obtained by fatty acid modification of the main chain structure or contralateral chain group of polypeptide drugs, which can also be used for a number of different applications, for example, improving drug solubility and absorption, prolonging the half-life of peptide drugs in the circulation and enhancing plasma albumin binding rate.
NHS-Activated Peptide Conjugation Magnetic Beads, also called immunomagnetic microspheres, is a small spherical particle with superparamagnetic and protective shell, which is mainly used in the field of separation and purification, such as protein separation and purification, antibody separation and purification.
Peptide-imaging agent conjugation is a molecular probe that can be used for organ, tissue, or molecular imaging. After peptide-imaging agent conjugation is introduced into the body, it can concentrate in the target organ or tissue, detect the radiation emitted by the imaging instrument, and obtain the distribution image of the drug in the body, which can be used to diagnose various diseases.
Creative Peptides has developed a reliable method for custom conjugation, and we will provide custom conjugation services to global customers with excellent technology. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. The experienced experts and advanced instruments in the Creative Peptides can meet all your needs for peptides conjugation. We will provide you with a full range of synthesis and modification services. As a partner in your research, we look forward to deeper cooperation. Please contact us!
1. Schmitz, M., Kuhlmann, M., Reimann, O., Hackenberger, C. P., & Groll, J. (2015). Side-chain cysteine-functionalized poly (2-oxazoline) s for multiple peptide conjugation by native chemical ligation. Biomacromolecules, 16(4), 1088-1094.
2. Zhao, M., Kircher, M. F., Josephson, L., & Weissleder, R. (2002). Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjugate chemistry, 13(4), 840-844.
3. Stetsenko, D. A., & Gait, M. J. (2000). Efficient conjugation of peptides to oligonucleotides by “native ligation”. The Journal of organic chemistry, 65(16), 4900-4908.