Custom Conjugation Service
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Custom Conjugation Service

* Please be kindly noted that our services can only be used for research to organizations or companies and not intended for individuals.

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Custom-Conjugation-Service-1-1.pngLeveraging our expertise and knowledge in peptides manufacturing, Creative Peptides provides convenient multiple types of peptide conjugation services to meet the needs of different projects, including activating immune responses, obtaining higher stability and cell penetration.

We offer peptide conjugation services using antibodies, proteins, oligonucleotides, nanoparticles, etc., as well as other characteristics and quality assessments of the combined products.

Available Peptide Conjugation Services

If you need a conjugation not listed below, or have any questions about peptide conjugation, please feel free to contact us. You will receive a reply within 24 hours.

Gold/Silver Nanoparticles Conjugation ServicePeptide-enzyme ConjugationPeptide-RNA Conjugation
NHS-Activated Peptide Conjugation Magnetic BeadsPeptides-Fatty Acids ConjugationPeptide-small-molecule Conjugation
Peptide-Antibody ConjugationPeptides-Imaging Agents ConjugationPeptide-siRNA Conjugation
Peptides-Carraier Protein ConjugationPeptides-Metal Chelates Conjugation 
Peptide-DNA ConjugationPeptide-oligonucleotide Conjugation 
  1. Gold/Silver Nanoparticles Conjugation Service

Scientific research on nanoparticles (NPs) is intense as they have many potential applications in medicine, physics, optics, and electronics. NPs can be used to deliver a cargo, such as an anticancer drug, or a cohort of radionuclide atoms to a targeted region of the body.

  1. Peptides-Carraier Protein Conjugation

Allow the induction of a B-cell response to the entire immunogen, including the peptide. New synthetic peptides thus offer promise as vaccines.

  1. Peptide-oligonucleotide Conjugation

Conjugated oligonucleotides and peptides by covalent attachment can enhance the function of the oligonucleotide. Studies have shown that peptide and oligonucleotide conjugates have stronger target cell penetration and higher cell absorption efficiency than unmodified oligonucleotides.

  1. Peptide-enzyme Conjugation

Peptide enzyme conjugates can detect immune complexes by visual or spectrophotometry as sensitive probes. Enzyme labels provide the best overall performance, high sensitivity, low background, and can achieve fast detection.

  1. Peptides-Metal Chelates Conjugation

Peptides-Metal Chelates Conjugation is a kind of compound with cyclic structure which is formed by chelation reaction between peptide and metal ions. It can improve the bioavailability of metal ions by means of the absorption mechanism of peptides in the body, and has physiological and biochemical characteristics that inorganic metal ions do not have.

  1. Peptides-Fatty Acids Conjugation

Peptides-Fatty acids Conjugation is obtained by fatty acid modification of the main chain structure or contralateral chain group of polypeptide drugs, which can also be used for a number of different applications, for example, improving drug solubility and absorption, prolonging the half-life of peptide drugs in the circulation and enhancing plasma albumin binding rate.

  1. NHS-Activated Peptide Conjugation Magnetic Beads

NHS-Activated Peptide Conjugation Magnetic Beads, also called immunomagnetic microspheres, is a small spherical particle with superparamagnetic and protective shell, which is mainly used in the field of separation and purification, such as protein separation and purification, antibody separation and purification.

  1. Peptides-Imaging Agents Conjugation

Peptide-imaging agent conjugation is a molecular probe that can be used for organ, tissue, or molecular imaging. After peptide-imaging agent conjugation is introduced into the body, it can concentrate in the target organ or tissue, detect the radiation emitted by the imaging instrument, and obtain the distribution image of the drug in the body, which can be used to diagnose various diseases.

  1. Peptides-Fatty Acids Conjugation

To improve peptide pharmacokinetics, conjugating the peptide to lipids is a favored approach. Peptides-Fatty acids conjugation is obtained by fatty acid modification of the main chain structure or contralateral chain group of polypeptide drugs.

  1. Peptide-small-molecule Conjugation

Peptide can be coupled with various small molecules, such as fluorophores, chelating agents, and therapeutics. Peptide-small-molecule conjugates have the characteristics of good selectivity, low immunogenicity, good biocompatibility, strong permeability, and easy excretion, which can be used in tumor-targeted molecular diagnosis.

  1. Peptide-Antibody Conjugation

Peptide-Antibody Conjugation technology can further improve the accuracy of peptide delivery based on the guidance of antibodies and facilitates the delivery of conjugate aprotinin-derived peptides across the blood-brain barrier.

  1. Peptide-siRNA Conjugation

Peptide-siRNA Conjugation technology is to use peptides as a carrier of nucleic acids to bring short siRNA into the body, exert its gene silencing effect, and specifically silence the expression of target genes to achieve therapeutic purposes.

  1. Peptide-DNA Conjugation

Peptide-DNA conjugates are molecular chimeras composed of nucleic acid moieties covalently attached to polypeptide parts and are used in a variety of applications such as therapy and nanotechnology. A common strategy is to combine a cell-penetrating carrier peptide with a phosphorosulfate DNA chain that enhances the nuclease attack ability.

  1. Peptide-RNA Conjugation

Peptide-RNA conjugate is considered a useful drug because its stability is much better than RNA. Methods for preparing peptide-RNA conjugates include: post-synthesis coupling method (or post-assembly coupling method and fragment coupling method), fully stepwise synthesis method (or online solid-phase synthesis method), natural coupling method and template orientation coupling method.

Main Advantages

  1. Highly stable conjugate
  2. Muti-type conjugations available
  3. Save time and cost

Creative Peptides has developed a reliable method for custom conjugation, and we will provide custom conjugation services to global customers with excellent technology. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. The experienced experts and advanced instruments in the Creative Peptides can meet all your needs for peptides conjugation. We will provide you with a full range of synthesis and modification services. As a partner in your research, we look forward to deeper cooperation. Please contact us!

References
1. Schmitz, M., Kuhlmann, M., Reimann, O., Hackenberger, C. P., & Groll, J. Side-chain cysteine-functionalized poly (2-oxazoline) s for multiple peptide conjugation by native chemical ligation. Biomacromolecules. 2015; 16(4):1088-1094.
2. Zhao, M., Kircher, M. F., Josephson, L., & Weissleder, R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjugate Chemistry. 2002; 13(4): 840-844.
3. Stetsenko, D. A., & Gait, M. J. Efficient conjugation of peptides to oligonucleotides by "native ligation". The Journal of Organic Chemistry. 2000; 65(16):4900-4908.

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.

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