Nucleotides and Nucleosides

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

CAT# Product Name M.W Molecular Formula Inquiry
CP25119 Boc-L-Pro(4-keto)-OMe 243,26 g/mole C10H17NO5 Inquiry
HB00070 1-methyl-D-tryptophan 218.25 C12H14N2O2 Inquiry
L-OS-0102 2'-O-(2-Methoxyethyl)-uridine C12H18N2O7 Inquiry
L-OS-0103 2'-O-(2-Methoxyethyl)-5-Methyluridine C13H20N2O7 Inquiry
L-OS-0104 2'-O-(2-Methoxyethyl)-cytidine C12H19N3O6 Inquiry
L-OS-0105 2'-O-(2-Methoxyethyl)-5-methylcytidine C13H21N3O6 Inquiry
L-OS-0106 2'-O-(2-Methoxyethyl)-adenosine C13H19N5O6 Inquiry
L-OS-0107 5'-O-DMTr-2'-O-(2-Methoxyethyl)-uridine C33H36N2O9 Inquiry
L-OS-0108 5'-O-DMTr-2'-O-(2-Methoxyethyl)-5-methyluridine C34H38N2O9 Inquiry
L-OS-0109 N-Benzoyl-5'-ODMTr-2'-O-(2-methoxyethyl)-adenosine C41H41N5O8 Inquiry
L-OS-0110 N-Benzoyl-5'-ODMTr-2'-O-(2-Methoxyethyl)-5-methyl-cytidine C41H43N3O9 Inquiry
L-OS-0111 N-Benzoyl-5'-ODMTr-2'-O-(2-Methoxyethyl)-cytidine C40H41N3O9 Inquiry
L-OS-0112 2-Thiothymidine C10H14IN2O4S Inquiry
L-OS-0113 2-O-Ethylthymidine C12H18N2O5 Inquiry
L-OS-0114 2-O-MethylThymidine C11H16N2O5 Inquiry
L-OS-0115 2,2'-Cyclouridine C9H12N2O5 Inquiry
L-OS-0116 2,2'-Cyclothymidine C10H14N2O5 Inquiry
L-OS-0117 2'-Azido-2'-deoxyuridine C9H11N5O5 Inquiry
L-OS-0118 2'-Amino-2'-deoxyuridine C9H13N3O5 Inquiry
L-OS-0119 2'-Azido-2'-deoxy-5-methyl uridine C10H13N5O5 Inquiry

Definition of Nucleosides

Pentose and purine bases or pyrimidine bases are linked by glycosidic bonds called nucleosides. The nucleosides in RNA are composed of ribose as the sugar group and are called ribonucleosides. The sugar group in DNA is deoxyribose, so it is called deoxyribonucleoside. There are adenine deoxynucleosides, guanine deoxynucleosides, thymine deoxynucleosides and cytosine deoxynucleosides in DNA. In various nucleosides, the first carbon atom (C-1) of the sugar group is connected to the base through the N atom of the base. If the base is pyrimidine, the first nitrogen atom (N-1) of the base is bound; if the base is purine, the 9th nitrogen atom (N-9) of the base is bound.

Definition of Nucleotide

The pentose hydroxyl group in the nucleoside and the phosphoric acid are linked together in the form of a phosphate bond to form a nucleotide. Nucleotides in most organisms are first phosphorylated by the hydroxyl group on C-5 of ribose or deoxyribose to form nucleoside monophosphates. The nucleoside monophosphate is further phosphorylated to produce nucleoside diphosphate and nucleoside triphosphate. Take ribonucleotides as an example. In addition to AMP, there are two forms of adenosine diphosphate (ADP) and adenosine triphosphate (ATP). The diphosphates and triphosphates of nucleotides are mostly metabolic intermediates related to nucleotides or regulatory substances of enzyme activity and metabolism, and they are also important forms of physiological energy storage and provision of energy.

Antiviral mechanism of nucleoside and nucleotide analogs (NAs)

Nucleoside and nucleotide analogs (NAs) are an important class of drugs clinically used to treat viral infectious diseases, tumors, and AIDS. NAs account for more than half of the antiviral drugs currently on the market, which play an important role in antiviral therapy. NAs are used as viral polymerase or reverse transcriptase inhibitors. After entering the cell, they are gradually phosphorylated into nucleoside triphosphate analogs to exert antiviral effects. NAs inhibit virus replication through one or more non-mutation mechanisms. First, the incorporation of exogenous nucleotides during viral genome replication may cause the termination of replication. Secondly, NAs may bind to the extended nucleotide chain, causing natural nucleotide mismatches or substitutions, thereby introducing mutations and impairing RNA synthesis or protein expression. Through these mechanisms, NAs change the genetic composition of the virus, leading to the death of the virus. Creative Peptides is committed to providing customers with a rich variety of nucleotides and nucleosides analogs.

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Customer Support & Price Inquiry

Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!

 Studies on the binding affinities of darifenacin hydrobromide and human muscarinic receptor subtypes show strong ...

 Endothelin-1 (ET-1) is a vasoactive peptide containing 21 amino acids, which was first isolated from the culture ...

 Antazoline is a drug used in the treatment of atrial fibrillation (AF), and its formula is C17H19N3. In fact, th ...

 Jingzhaotoxin-III (β-TRTX-Cj1α) is a kind of sodium channel gating modifier which is from the tarantula Chilobra ...

 The toxin BeKm 1 is a HERG-specific peptide toxin, which are voltage-gated K+ channels, coded by the human ether ...

Quick Inquiry
×
Contact Us

USA

Address:

Tel: |

Email:

Germany

Address:

Copyright © 2024 Creative Peptides. All rights reserved.