Peptide C-Terminal Modification
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Peptide C-Terminal Modification

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The development and importance of C-terminal modification of peptides

Peptide-C-Terminal-Modification.pngThe posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then, more than a hundred proteins have been shown to be modified by C15 farnesyl or C20 geranylgeranyl groups, including most members of the Ras, Rho, and Rab familied of G proteins. The C-terminal of the peptide is synthesized as an amide to neutralize negative charge created by the C-terminal COOH. This modification is added to prevent enzyme degradation, to mimic native proteins, and in some cases to remove hydrogen bonding at the C-terminal of the peptides which may interfere with the assays.

Available C-Terminal Modification Services

Creative Peptides provides multiple peptides of C-terminal modification to meet your custom peptide need. These peptide modifications can be used to create synthetic peptide with the exact conformation of characteristics needed for specific applications.

Below is a list of our available modification (include but not limited to the following):

> AFC> AMC> Acryl
> Amidation> Bzl> Cysteamide
> Ethylamine> MAPS Asymmetric 2/4/8 branches> Me
> NHEt> NHisopen> NHMe
> OSU> p-Nitroanilide> tBu
> Thioester> C-terminal esters> OEt
> OBzl> OtBu> OMe
> CMK> TBzl> FMK
> Peptide alcohols and aldehydes modification

Creative Peptides specialized in the custom synthesis of C-terminal modification peptides, providing a confidential and efficient service at competitive prices. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. Typical delivery specifications include:

  1. HPLC chromatogram
  2. Mass spec analysis
  3. Synthesis repor
  4. Certificate of Analyses

References:
[1] Amaya, M., Baranova, A., & van Hoek, M. L. (2011). Protein prenylation: A new mode of host–pathogen interaction. Biochemical and biophysical research communications, 416(1-2), 1-6.
[2] Kim, K. H., & Seong, B. L. (2001). Peptide amidation: Production of peptide hormonesin vivo andin vitro. Biotechnology and Bioprocess Engineering, 6(4), 244-251.

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
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