Publications
Home > Publications > Cationic cell-penetrating peptides are potent furin inhibitors

If you find Creative Peptides is useful to satisfy your needs, please do not hesitate to contact us!

Cationic cell-penetrating peptides are potent furin inhibitors

Ramos-Molina, B., Lick, A. N., Shirazi, A. N., Oh, D., Tiwari, R., El-Sayed, N. S. & Lindberg, I. PloS one 10.6 (2015): e0130417.

Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins. These reagents are chemically similar to the multi-basic peptides that are known to be potent proprotein convertase inhibitors. Here, we report that both HIV-1 TAT47-57 peptide and the Chariot reagent are micromolar inhibitors of furin activity in vitro. In agreement, HIV-1 TAT47-57 reduced HT1080 cell migration, thought to be mediated by proprotein convertases, by 25%. In addition, cyclic polyarginine peptides containing hydrophobic moieties which have been previously used as transfection reagents also exhibited potent furin inhibition in vitro and also inhibited intracellular convertases. Our finding that cationic cell-penetrating peptides exert potent effects on cellular convertase activity should be taken into account when biological effects are assessed.

Products Used in this Publication

Cat. # Product Name Price
T04003 HIV-1 tat Protein (47-57) Inquiry

Related Products

Cat. # Product Name Price
GR1203 HIV-1 TAT (48-60) Inquiry
T04002 HIV-1 tat Protein (1-9) Inquiry
T04004 HIV-1 tat Protein (49-57) Inquiry
T04005 HIV-1 tat Protein (48-57) Inquiry
T04006 HIV-1 TAT Protein Peptide Inquiry

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

Follow us on:

Copyright © 2008 - Creative Peptides. All rights reserved.

USA

Address: 45-16 Ramsey Road, Shirley, NY 11967, USA

Tel: 1-631-624-4882

Fax: 1-631-614-7828

E-Mail:

Europe

Tel: 44-207-097-1828

E-Mail: