Carperitide is a human atrial natriuretic peptide analog for heart and kidney research. Buy Carperitide peptide online to study diuretic and cardiovascular effects.
CAT No: HB00119
CAS No:89213-87-6
Synonyms/Alias:Carperitide;89213-87-6;Cardionatrin;Atriopeptin;alpha-Atriopeptin;Atrial Natriuretic Peptide;Atriopeptins;Auriculin (peptide);Atrial natriuretic peptide A;SUN-4936;Atrial natriuretic peptides;Natriuretic peptides, atrial;Atrial natriuretic factor (99-126);Atrial natriuretic peptide-28 (human reduced);ATRIAL NATRIURETIC FACTOR;85637-73-6;SUN 4936;alpha-Human atriopeptin;Atriopeptin-28 (human);alpha-Atriopeptin (human);Human atriopeptin(1-28);Human atriopeptin(99-126);CCRIS 4930;Atrial Natriuretic Peptide human;Triopeptin (human alpha-component);Carperitide [USAN:INN];UNII-GZ8FA500J0;Cardionatrine;Carperitida;NPPA protein, human;Anp 1-28,human;Atrial natruiretic factor;Natriuretic Peptide, Atrial;Peptides, Atrial Natriuretic;SCHEMBL218549;beta-Atrial Natriuretic Peptide;GZ8FA500J0;alpha-Atrial Natriuretic Peptide;Atrial Natriuretic Factor (1-28) (human) acetate salt;atrial natriuretic factor (ANF);CHEMBL2104386;gamma-Atrial Natriuretic Peptide;CHEBI:135914;NSQLIUXCMFBZME-MPVJKSABSA-N;DTXSID201346607;DTXSID801026506;Atrial Natriuretic Factor Precursors;BDBM50230986;Atrial natriuretic peptide carperitide;AKOS024456845;AT42445;ATRIAL NATRIURETIC PEPTIDE [MI];Atriopeptin-33(rat), 1-de-L-leucine-2-de-L-alanine-3-deglycine-4-de-L-proline-5-de-L-arginine-17-L-methionine-;DA-50791;FA108602;FA110232;L-Seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine cyclic(7->23)-disulfide;L-Seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine cyclic(7-23)-disulfide;ATRIAL NATRIURETIC PEPTIDE [WHO-DD];NS00123867;1366000-58-9;Atrial natriuretic factor (1-28) (human) acetate;Atrial natriuretic factor (1-28) trifluoroacetate;1621001-83-9;Carperitide trifluoroacetate;H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala- Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser- Phe-Arg-Tyr-OH trifluoroacetate (Disulfide bond);H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH acetate;
Carperitide, also known as atrial natriuretic peptide (ANP), is a synthetic peptide corresponding to the naturally occurring human hormone secreted by atrial myocytes. As a member of the natriuretic peptide family, Carperitide is characterized by its ability to regulate fluid balance, vascular tone, and sodium homeostasis through its interaction with specific natriuretic peptide receptors. The compound is widely utilized in research settings to explore cardiovascular physiology, renal function, and the intricate signaling pathways involved in homeostatic regulation. Its structural similarity to endogenous ANP allows for precise experimental manipulation and evaluation of natriuretic peptide-mediated effects in various biological systems, making Carperitide a valuable tool for scientific inquiry.
Cardiovascular Research: In cardiovascular research, Carperitide is frequently employed to investigate the mechanisms of vasodilation, natriuresis, and diuresis. Researchers utilize the peptide to study its effects on vascular smooth muscle cells, endothelial function, and the modulation of blood pressure. By mimicking the action of endogenous ANP, it enables scientists to dissect the roles of natriuretic peptides in cardiac load reduction and hemodynamic regulation. Its application in experimental models helps clarify the interplay between cardiac hormones and neurohumoral factors in the context of cardiovascular diseases, contributing to the development of novel therapeutic strategies.
Renal Physiology Studies: Carperitide serves as a critical reagent in renal physiology studies, where it is used to elucidate the molecular mechanisms underlying sodium excretion and water balance. Researchers leverage its natriuretic and diuretic properties to examine renal tubular responses, glomerular filtration rate modulation, and the regulation of renal blood flow. The peptide's ability to activate guanylyl cyclase-linked receptors provides insights into cGMP-mediated signaling pathways, advancing the understanding of kidney function and the hormonal control of fluid and electrolyte homeostasis.
Signal Transduction Pathway Analysis: As a potent stimulator of cyclic guanosine monophosphate (cGMP) production, Carperitide is instrumental in studies focused on signal transduction pathways. Scientists employ the compound to investigate the downstream effects of natriuretic peptide receptor activation, including protein kinase G activation and subsequent cellular responses. Its use facilitates the dissection of complex intracellular signaling networks, contributing to the identification of novel targets for pharmacological intervention and the broader comprehension of cell signaling dynamics.
Vascular Biology Investigations: In the field of vascular biology, Carperitide is utilized to study endothelial cell function, vascular permeability, and the mechanisms of angiogenesis. The peptide's vasodilatory action is exploited to explore the interplay between nitric oxide and natriuretic peptide signaling in vascular homeostasis. Experimental applications include assessing its impact on vascular smooth muscle relaxation, endothelial barrier integrity, and the modulation of inflammatory responses within the vasculature, providing valuable data for vascular pathophysiology research.
Pharmacological Screening and Drug Discovery: Carperitide is also featured in pharmacological screening assays and drug discovery efforts, where it serves as a reference compound for evaluating the efficacy of novel agents targeting natriuretic peptide receptors or related pathways. By providing a well-characterized model for receptor activation and downstream signaling, the peptide aids in the identification and optimization of small molecules or biologics with potential therapeutic applications. Its role in assay development and validation ensures reliable and reproducible results, thereby accelerating the pace of innovation in cardiovascular and renal pharmacology.
In summary, Carperitide is an indispensable tool in a diverse array of research applications, including cardiovascular research, renal physiology studies, signal transduction pathway analysis, vascular biology investigations, and pharmacological screening and drug discovery. Its unique biochemical properties and close resemblance to endogenous atrial natriuretic peptide enable precise experimental manipulation, fostering advances in basic and translational science across multiple disciplines. The compound's versatility and scientific relevance continue to drive new discoveries in the regulation of fluid balance, vascular function, and cellular signaling, highlighting its enduring value in biomedical research.
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