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|CAT#||Product Name||M.W||Molecular Formula||Inquiry|
|E1503||Acetyl-(Cys(Acm)33.42)-EGF (33-42) amide (mouse)||1255.44||Inquiry|
|G09018||(Phenylac-Tyr1,D-Arg2,p-chloro-Phe6,Arg9,Abu15,Nle27,D-Arg28,Homoarg29)-GRF (1-29) amide (human)||3757.88||Inquiry|
|G09019||(Phenylac-Tyr1,D-Arg2,p-chloro-Phe6,Homoarg9,Tyr(Me)10,Abu15,Nle27,D-Arg28,Homoarg29)-GRF (1-29) amide (human)||3785.93||Inquiry|
|T10003||TGF α (34-43) (rat)||1078.24||C44H67N15O13S2||Inquiry|
Growth factor is a natural substance, which can stimulate cell growth, proliferation, healing and cell differentiation, which play an important role in the regulation of a variety of cell processes. Growth factors are usually used as intercellular signaling molecules, such as cytokines and hormones bind to specific receptors on the surface of the target cell. They usually promote cell differentiation and maturation, which are different in different growth factors. For example, epidermal growth factor (EGF) promotes osteogenic differentiation, while fibroblast growth factor and vascular endothelial growth factor stimulate vascular differentiation (angiogenesis).
Cytokine receptors can be composed of multiple peptide chains in the form of homodimers or heterodimers. Interleukin-2 receptor (IL-2R) has three forms of high, moderate and low affinity, which are composed of α chain monomer, β and γ chain dimer, and α, β and γ chain trimer, respectively. This also suggests that the common peptide chain structure of other cytokines is similar to that of IL-2R. Darnell reveals the transduction information of INF through tyrosinase JAK-JAK substrate (JAK-STATs) pathway in interferon-α (INF-α) and interferon-γ (INF-γ) models. At present, it has been confirmed that the special activities of six STATs, cytokines can form unique STATs homomorphism and heterodimerization. When many signal transduction pathways do not contain JAKs or TATs, the heteropolymerization of transducers can lead to essentially different biological effects.
The effects of many peptide growth factors include stimulating and inhibiting cell proliferation and are not related to cell growth control. A peptide can have both stimulating and inhibitory activities in a single cell, depending on the context in which other signaling molecules exist. New approaches for cancer therapy are being developed that intervene at various steps in growth factor signaling pathways.