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|CAT#||Product Name||M.W||Molecular Formula||Inquiry|
|S07018||(D-2-Nal5,Cys6·11,Tyr7,D-Trp8,Val10,2-Nal12)-Somatostatin-14 (5-12) amide||1192.47||Inquiry|
Somatostatin, also known as growth hormone-inhibiting hormone (GHIH), which is a hypothalamic peptide hormone and can inhibit the secretion of growth hormone, glucagon, insulin, gastrin and secretory hormone, and play a role in neurotransmission. Somatostatin has two active forms: one is composed of 14 amino acids, the other is composed of 28 amino acids.
Somatostatin is distributed all over the human body, but it is especially abundant in the cortex, hypothalamus, brainstem and spinal cord and other nerve tissues. Somatostatin has also been found in the nerves of the heart, thyroid, skin, eyes and thymus. The gastrointestinal tract and pancreas are rich in somatostatin, which is produced by paracrine and endocrine-like D cells and through intestinal nerves. Somatostatin-14 and somatostatin-28 were expressed in the whole gastrointestinal tract.
To sum up, somatostatin and its long-acting analogues have good curative effect in the treatment of a variety of clinical diseases. In addition to its direct endocrine inhibition, its indirect inhibition of secretion, contraction of visceral blood vessels and anti-tumor activity make this kind of drugs become an effective means of clinical refractory diseases. In order to avoid abuse, more research is still needed to support its positive effect on disease remission and survival prognosis. At the same time, efforts should be made to develop a new generation of preparations with fewer side effects and better curative effect.