Vapreotide is a somatostatin analog with a higher metabolic stability than the parent hormone. Vapreotide reduces splanchnic blood flow, inhibits growth hormone release, and inhibits the release of peptides and vasoactive compounds from neuroendocrine tumors.
CAT No: 10-101-44
CAS No: 103222-11-3 (net), 116430-60-5 (acetate) 849479-74-9(ChemIDplus)
Synonyms/Alias: Vapreotide acetate;116430-60-5;Docrised;OCTASTATIN ACETATE;RC-160 acetate;Vapreotide monoacetate;Octastatin;Sanvar;BMY-41606 acetate;Vapreotide acetate [MI];Vapreotide acetate [WHO-DD];5562377HFV;DP-05-094;acetic acid;(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide;UNII-5562377HFV;Vapreotide acetate [USAN];849479-74-9;L-Tryptophanamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2->7)-disulfide, acetate (salt);L-Tryptophanamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2->7)-disulfide, monoacetate (salt);BMY-41606;Vapreotide acetate (USAN);RC-160;Docrised (mexico);Debio-8609;SCHEMBL294911;EX-A7487A;Vapreotide acetate [USAN:WHO-DD];G13841;Q27261277;D-Phenylalanyl-L-Cysteinyl-L-Tyrosyl-D-Tryptophyl-L-Lysyl-L-Valyl-L-Cysteinyl-L-Tryptophanamide Cyclic (2->7)-Disulphide Acetate Salt (1:N);L-Tryptophanamide, D-Phenylalanyl-L-Cysteinyl-L-Tyrosyl-D-Tryptophyl-L-Lysyl-L-Valyl-L-Cysteinyl-, Cyclic (2->7)-Disulfide, Acetate (1:N);
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M.F/Formula | C59H74N12O11S2 |
M.W/Mr. | 1191.4 |
Sequence | One Letter Code:FCYWKVCW Three Letter Code:H-D-Phe-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Trp-NH2.CH3CO2H |
Application | Vapreotide is a synthetic octapeptide somatostatin analog with a different receptor affinity to octreotide. It is used for the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea. |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
InChI | InChI=1S/C57H70N12O9S2.C2H4O2/c1-32(2)49-57(78)68-48(55(76)64-44(50(60)71)26-35-28-61-41-16-8-6-14-38(35)41)31-80-79-30-47(67-51(72)40(59)24-33-12-4-3-5-13-33)56(77)65-45(25-34-19-21-37(70)22-20-34)53(74)66-46(27-36-29-62-42-17-9-7-15-39(36)42)54(75)63-43(52(73)69-49)18-10-11-23-58;1-2(3)4/h3-9,12-17,19-22,28-29,32,40,43-49,61-62,70H,10-11,18,23-27,30-31,58-59H2,1-2H3,(H2,60,71)(H,63,75)(H,64,76)(H,65,77)(H,66,74)(H,67,72)(H,68,78)(H,69,73);1H3,(H,3,4)/t40-,43+,44+,45+,46-,47+,48+,49+;/m1./s1 |
InChI Key | KBIZSMHYSQUHDH-NCACADTJSA-N |
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