Vapreotide Acetate

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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ExplanationVapreotide is a somatostatin analog with a higher metabolic stability than the parent hormone. Vapreotide reduces splanchnic blood flow, inhibits growth hormone release, and inhibits the release of peptides and vasoactive compounds from neuroendocrine tumors.
Synonyms/AliasRC-160; Octastatin; RC 160; RC160; Vapreotida; DB04894
SequenceThree Letter Code: D-Phe-Cys-Trp-D-Trp-Lys-Val-Cys-Trp-CONH2(disulfide Cys2-Cys7)
ApplicationVapreotide is a synthetic octapeptide somatostatin analog with a different receptor affinity to octreotide. It is used for the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
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