Elcatonin acetate inhibits the absorption and autolysis of bones, thus leads to blood calcium descending. In addition, it inhibits the bone salts dissolving and transferring and promotes the excretion of calcium and phosphorus in urine.
CAT# | 10-101-13 |
CAS | 60731-46-6 (net) |
Background | Elcatonin is a synthetic analog of eel calcitonin that exhibits analgesic, anti-allodynic, antacid, and anti-resorptive activities. In animal models, elcatonin inhibits the effects of thermal and mechanical pain; it also decreases hyperalgesia induced by chronic constrictive injury. When administered clinically, elcatonin decreases symptoms of gastroesophageal reflux disease (GERD), such as heartburn and acid reflux. Additionally, this peptide induces osteoblast proliferation and prevents bone resorption and decreases in bone mineral density in animal models of bone injury. >> Read More |
Synonyms/Alias | Carbocalcitonin; Elcatonine; Elcatoninum; Elcatonina; HC-58; HC58; HC 58; LS-61711; LS61711; LS 61711;DL-cysteinyl-DL-seryl-DL-asparagyl-DL-leucyl-DL-seryl-DL-threonyl-DL-cysteinyl-DL-valyl-DL-leucyl-glycyl-DL-lysyl-DL-leucyl-DL-seryl-DL-glutaminyl-DL-alpha-glutamyl-DL-leucyl-DL-histidyl-DL-lysyl-DL-leucyl-DL-glutaminyl-DL-threonyl-DL-tyrosyl-DL-prolyl-DL-arginyl-DL-threonyl-DL-alpha-aspartyl-DL-valyl-glycyl-DL-alanyl-glycyl-DL-threonyl-DL-prolinamide (1->7)-disulfide |
Chemical Name | 4-[[5-amino-2-[[2-[[2-[[6-amino-2-[[2-[[2-[[2-[[22-amino-16-(2-amino-2-oxoethyl)-7-(1-hydroxyethyl)-10,19-bis(hydroxymethyl)-13-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-[[1-[[1-[[6-amino-1-[[1-[[5-amino-1-[[1-[[1-[2-[[5-carbamimidamido-1-[[1-[[1-[[1-[[2-[[1-[[2-[[1-(2-carbamoylpyrrolidin-1-yl)-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
M.F/Formula | C148H244N42O47 |
M.W/Mr. | 3363.8 |
Sequence | One Letter Code: CSNLSXCVLGKLSQELHKLQXYPRXDVGAGXP Three Letter Code: H-DL-Cys(1)-DL-Ser-DL-Asn-DL-Leu-DL-Ser-DL-xiThr-DL-Cys(1)-DL-Val-DL-Leu-Gly-DL-Lys-DL-Leu-DL-Ser-DL-Gln-DL-Glu-DL-Leu-DL-His-DL-Lys-DL-Leu-DL-Gln-DL-xiThr-DL-Tyr-DL-Pro-DL-Arg-DL-xiThr-DL-Asp-DL-Val-Gly-DL-Ala-Gly-DL-xiThr-DL-Pro-NH2 |
Application | Elcatonin acetate, a synthetic eel calcitonin analog, positively influences bone mass density due to its inhibiting effect on osteoclast activity. It is mainly used for remitting or eliminating the pain caused by Osteoporosis. |
Areas of Interest | Osteoporosis Research |
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