Home > Product > APIs > Elcatonin Acetate

APIs

Elcatonin Acetate

Price Inquiry
CAT#
10-101-13
Synonyms/Alias
Carbocalcitonin; Elcatonine; Elcatoninum; Elcatonina; HC-58; HC58; HC 58; LS-61711; LS61711; LS 61711
CAS No.
60731-46-6 (net)
Sequence
Cyclo(-Ser-Asn-Leu-Ser-Thr-Asu)-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 acetate salt
M.W/Mr.
3363.8
Molecular Formula
C148H244N42O47
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
Elcatonin acetate, a synthetic eel calcitonin analog, positively influences bone mass density due to its inhibiting effect on osteoclast activity. It is mainly used for remitting or eliminating the pain caused by Osteoporosis.
Description
Elcatonin acetate inhibits the absorption and autolysis of bones, thus leads to blood calcium descending. In addition, it inhibits the bone salts dissolving and transferring and promotes the excretion of calcium and phosphorus in urine.
Areas of Interest
Diseases
  • Background
  • Related Products
  • References

Elcatonin is a synthetic analog of eel calcitonin that exhibits analgesic, anti-allodynic, antacid, and anti-resorptive activities. In animal models, elcatonin inhibits the effects of thermal and mechanical pain; it also decreases hyperalgesia induced by chronic constrictive injury. When administered clinically, elcatonin decreases symptoms of gastroesophageal reflux disease (GERD), such as heartburn and acid reflux. Additionally, this peptide induces osteoblast proliferation and prevents bone resorption and decreases in bone mineral density in animal models of bone injury.

CAS: 154-68-7 (phosphate),2508-72-7 (hydrochloride),24359-81-7(Sulfate)
Sequence: ---
M.W: 363.35
Molecular Formula: C17H19N3·H2O4S
CAS: 17035-90-4 (net), 53308-83-1 (acetate)
Sequence: H-Arg(Me)-OH acetate salt
M.W: 248.28
Molecular Formula: C9H20N4O4
CAS: 163913-87-9
Sequence: Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu -Tyr-Arg-Asn-Gly-Lys
M.W: 2581.99
Molecular Formula: C118H177N35O29S
CAS: 73385-60-1
Sequence: Tyr-Met(O)-Gly-(4-nitrophenyl)-Ala-ProNH2
M.W: 673.74
Molecular Formula: C30H39N7O9S
CAS: 3397-23-7
Sequence: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Orn-Gly-NH2(Disulfide,Cys1 and Cys6)
M.W: 1042.19
Molecular Formula: C45H63N13O12S2

The polypeptide hormone calcitonin is clinically well known for its ability to relieve neuropathic pain such as spinal canal stenosis, diabetic neuropathy and complex regional pain syndrome. Mechanisms for its analgesic effect, however, remain unclear. Here we investigated the mechanism of anti-hyperalgesic action of calcitonin in a neuropathic pain model in rats.

Ito, A., Takeda, M., Yoshimura, T., Komatsu, T., Ohno, T., Kuriyama, H., ... & Yoshimura, M. (2012). Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors. Molecular pain, 8(1), 42.

The study was carried out to determine the effect of a combination regimen of a small dose of calcitonin added to conjugated estrogens with medroxyprogesterone acetate on vertebral bone mass in early postmenopausal women. Comparisons were made with groups of women on calcitonin alone, on conjugated estrogens with medroxyprogesterone acetate alone, or on no treatment. The study was carried out over a 2-year period. The results of the study suggest that the combined regimen of calcitonin and estrogens increased vertebral bone mass in early postmenopausal women to a greater extent than calcitonin alone or estrogen alone. Increases in vertebral bone mass of 11.2% after 1 year and 9.2% after 2 years were demonstrated using the combined regimen. Both estrogens alone and calcitonin alone were, however, very effective in preventing rapid bone loss in the postmenopausal women studied.

Meschia, M., Brincat, M., Barbacini, P., Crossignani, P. G., & Albisetti, W. (1993). A clinical trial on the effects of a combination of elcatonin (carbocalcitonin) and conjugated estrogens on vertebral bone mass in early postmenopausal women. Calcified tissue international, 53(1), 17-20.

Online Inquiry

Name (First Last) *
Email *
Phone *
Service & Products of Interest *
Quantities
Purity
Services Required and Project Description
Verification code *Please enter the code "peptides"
Home | Site Map | Contact Us | Resources
Copyright © 2008 - Creative Peptides. All rights reserved.