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Terlipressin Acetate

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CAT#
10-101-38
Synonyms/Alias
glipressin; glycylpressin; glypressin; Remestyp; terlypressin; TGLVP; triglycylvasopressin; triglycyl lysine vasopressin; Terlipressine; Terlipressinum; Terlipressina; Terlipressina; EINECS 238-680-8; LS-161411
CAS No.
14636-12-5
Sequence
H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 acetate salt (Disulfide bond)
M.W/Mr.
1227.4
Molecular Formula
C52H74N16O15S2
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
Terlipressin has been used as a vasoactive drug in the management of low blood pressure. It also indicates to be used in norepinephrine-resistant septic shock and hepatorenal syndrome. In addition, it is used to treat bleeding esophageal varices.
Description
Terlipressin is a synthetic analog of vasopressin and is used as a vasoactive drug in the management of hypotension. It is a prodrug, which is converted to (Lys8)- vasopressin after removal of the N-terminal triglycine in vivo. Terlipressin has a longer duration of action and a better safety profile than the parent compound.
Areas of Interest
Vasoactive drug
  • Background
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  • References

Terlipressin is a synthetic peptide agonist at vasopressin 1 receptors (AVPR1) and is clinically used to treat portal hypertension by decreasing portal pressure; it is an analog of vasopressin. Terlipressin is a vasopressin analog that exhibits both vasoconstrictive and antihypertensive activities in various models. Terlipressin induces gastroparesis in vivo, increasing slow wave frequency in stomach and intestines. Terlipressin may also improve renal function in subjects with hepatorenal syndrome. Terlipressin Acetate is an analogue of vasopressin used as a vasoactive for proteomics research. It has been found to be effective when norepinephrine is not.

CAS: 56-59-7
Sequence: H-Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 acetate salt (Disulfide bond)
M.W: 1040.22
Molecular Formula: C46H65N13O11S2

Currently medical therapy is aimed at reducing splanchnic vasodilation to resolve the ineffective circulation and maintain good renal perfusion pressure. Terlipressin, a vasopressin analogue, has shown potential benefit in the treatment of HRS. It prolongs both survival time and has the ability to reverse HRS in the majority of patients. In this review we aim to focus on the pathogenesis of HRS and its treatment with terlipressin vs other drugs.

Magan, A. A., Khalil, A. A., & Ahmed, M. H. (2010). Terlipressin and hepatorenal syndrome: what is important for nephrologists and hepatologists. World journal of gastroenterology: WJG, 16(41), 5139.

Liver disease is usually accompanied with a decline in systemic vascular resistance (SVR). We decided to assess effects of the peri-operative terlipressin infusion on liver donor liver transplantation recipients with respect to haemodynamics and renal parameters.

Ibrahim, N., Hasanin, A., Allah, S. A., Sayed, E., Afifi, M., Yassen, K., ... & Khalil, M. (2015). The haemodynamic effects of the perioperative terlipressin infusion in living donor liver transplantation: A randomised controlled study. Indian journal of anaesthesia, 59(3), 156.

Terlipressin and somatostatin are the most preferable agents for the control of variceal bleeding in cirrhotic patients. The present study evaluated the hemodynamic effects of somatostatin, terlipressin and somatostatin plus terlipressin in cirrhotic patients with portal hypertension, as well as the effect of each regimen on renal sodium excretion.

Kalambokis, G., Economou, M., Paraskevi, K., Konstantinos, P., Pappas, C., Katsaraki, A., & Tsianos, E. V. (2005). Effects of somatostatin, terlipressin and somatostatin plus terlipressin on portal and systemic hemodynamics and renal sodium excretion in patients with cirrhosis. Journal of gastroenterology and hepatology, 20(7), 1075-1081.

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