Deslorelin

Name: Deslorelin
Brand: Creative Peptides
SKU: R1948
Availability: MadeToOrder

Deslorelin is a gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen). It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland.

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CAT No: R1948

CAS No: 57773-65-6

Chemical Name: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

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Synonyms/Alias	Deslorelin;57773-65-6;Deslorelina;Desloreline;Somagard;D-Trp LHRH-PEA;Deslorelinum;D-Trp-LHRH-PEA;Bachem 9022;UNII-TKG3I66TVE;TKG3I66TVE;GNRH (D-Trp6,pro9-net);(D-Trp6,Pro9-NHEt)LH-RH;Desloreline [INN-French];Deslorelinum [INN-Latin];Deslorelina [INN-Spanish];(D-Trp6,des-Gly10)-LH-RH ethylamide;(de-Gly10,D-Trp6,Pro-NHEt)-LH-RH;(Des-Gly10(D-Tro6)-LH-RH ethylamide;(D-Trp(sub 6)-pro(sup 9)-NEt)-GNRH;(D-Trp6,des-Gly-NH210)-LH-RH ethylamide;DTXSID2048323;D-Trp(sup 6)-pro(sup 9)-N-ethylamide-LHRH;(D-Trp(sup 6)-pro(sup 9))-LHRH ethylamide;H 4065;Des-Gly-10-Trp-6-ethylamide-LHRH;GnRH, Trp(6)-N-Et-ProNH2(9)-;LHRH, Trp(6)-N-Et-ProNH2(9)-;GnRH, des-Gly(10)-Trp(6)-ethylamide-;LHRH, des-Gly(10)-Trp(6)-ethylamide-;6-Trp-9-N-Et-Pro-10-des-GlyNH2-LHRH;Desloreline (INN-French);Deslorelinum (INN-Latin);Deslorelina (INN-Spanish);DESLORELIN (MART.);DESLORELIN [MART.];LHRH, des-glycyl(10)-tryptophyl(6)-ethylamide-;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide;(D-TRP(SUP 6),DES-GLY(SUP 10))-LH-RH ETHYLAMIDE;LHRH, tryptophyl(6)-N-ethylprolinamide(9)-des-glycinamide(10)-;NCGC00167516-01;Deslorelin [USAN:INN:BAN];Deslorelin?;Deslorellin acetate;LHRH-T;DESLORELIN [MI];DESLORELIN [INN];Deslorelin (USAN/INN);DESLORELIN [USAN];DESLORELIN [WHO-DD];SCHEMBL59413;GTPL9343;CHEMBL2365665;DTXCID0028298;SCHEMBL19409316;BDBM84726;CHEBI:177570;GJKXGJCSJWBJEZ-XRSSZCMZSA-N;MFCD00167401;AKOS015994649;AC-8917;CS-5746;DB11510;HS-2009;NCGC00167516-02;NCGC00167516-03;HY-12556;6-D-phenylalanine-9-(N-ethyl-L-prolinamide)-;D03694;G78019;Q5264591;[des-Gly10, D-Trp6]-LH-RH ethylamide, >=97% (HPLC);6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine);Bachem 9022;D-Trp LHRH-PEA;
M.F/Formula	C64H83N17O12
M.W/Mr.	1282.4
Sequence	One Letter Code:XHWSYWLRP Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt
Appearance	Solid powder

Long-term Storage Conditions	Soluble in DMSO, not in water
InChI	InChI=1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1
InChI Key	GJKXGJCSJWBJEZ-XRSSZCMZSA-N
Canonical SMILES	CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
Isomeric SMILES	CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

1. The spatiotemporal control of signalling and trafficking of the GLP-1R

2. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

3. Therapeutic potential of an intestinotrophic hormone, glucagon-like peptide 2, for treatment of type 2 short bowel syndrome rats with intestinal bacterial and fungal dysbiosis

4. Immune responses to peptides containing homocitrulline or citrulline in the DR4-transgenic mouse model of rheumatoid arthritis

5. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

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Alarelin acetate

Alarelin acetate is a synthetic LH-RH agonist, and stimulates the release of FSH and LH from the pituitary gland. It is known for its induction of ovulation and used to treat endmometriosis.

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Glucagon

Glucagon (Porcine glucagon) is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon decreases the activity of HNF-4. Glucagon increases HNF4α phosphorylation.

Inquiry
GLP-1 (7-37) Acetate

Glucagon-like peptide-1 (GLP-1) is an incretin derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-2 as a gut hormone.

Inquiry
Teriparatide Acetate

Teriparatide(recombinant human parathyroid hormone) /PTH (1-34) (human) corresponds to the N-terminal part of human parathyroid hormone, a peptide consisting of 84 amino acids.

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Antide

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Deslorelin

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