Deslorelin peptide is a potent GnRH agonist used for fertility and hormonal control. Buy Deslorelin peptide powder online for veterinary and endocrine research applications.
CAT No: R1948
CAS No:57773-65-6
Synonyms/Alias:Deslorelin;57773-65-6;Deslorelina;Desloreline;Somagard;D-Trp LHRH-PEA;Deslorelinum;D-Trp-LHRH-PEA;Bachem 9022;UNII-TKG3I66TVE;TKG3I66TVE;GNRH (D-Trp6,pro9-net);(D-Trp6,Pro9-NHEt)LH-RH;Desloreline [INN-French];Deslorelinum [INN-Latin];Deslorelina [INN-Spanish];(D-Trp6,des-Gly10)-LH-RH ethylamide;(de-Gly10,D-Trp6,Pro-NHEt)-LH-RH;(Des-Gly10(D-Tro6)-LH-RH ethylamide;(D-Trp(sub 6)-pro(sup 9)-NEt)-GNRH;(D-Trp6,des-Gly-NH210)-LH-RH ethylamide;DTXSID2048323;D-Trp(sup 6)-pro(sup 9)-N-ethylamide-LHRH;(D-Trp(sup 6)-pro(sup 9))-LHRH ethylamide;H 4065;Des-Gly-10-Trp-6-ethylamide-LHRH;GnRH, Trp(6)-N-Et-ProNH2(9)-;LHRH, Trp(6)-N-Et-ProNH2(9)-;GnRH, des-Gly(10)-Trp(6)-ethylamide-;LHRH, des-Gly(10)-Trp(6)-ethylamide-;6-Trp-9-N-Et-Pro-10-des-GlyNH2-LHRH;Desloreline (INN-French);Deslorelinum (INN-Latin);Deslorelina (INN-Spanish);DESLORELIN (MART.);DESLORELIN [MART.];LHRH, des-glycyl(10)-tryptophyl(6)-ethylamide-;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide;(D-TRP(SUP 6),DES-GLY(SUP 10))-LH-RH ETHYLAMIDE;LHRH, tryptophyl(6)-N-ethylprolinamide(9)-des-glycinamide(10)-;NCGC00167516-01;Deslorelin [USAN:INN:BAN];Deslorelin?;Deslorellin acetate;LHRH-T;DESLORELIN [MI];DESLORELIN [INN];Deslorelin (USAN/INN);DESLORELIN [USAN];DESLORELIN [WHO-DD];SCHEMBL59413;GTPL9343;CHEMBL2365665;DTXCID0028298;SCHEMBL19409316;BDBM84726;CHEBI:177570;GJKXGJCSJWBJEZ-XRSSZCMZSA-N;MFCD00167401;AKOS015994649;AC-8917;CS-5746;DB11510;HS-2009;NCGC00167516-02;NCGC00167516-03;HY-12556;6-D-phenylalanine-9-(N-ethyl-L-prolinamide)-;D03694;G78019;Q5264591;[des-Gly10, D-Trp6]-LH-RH ethylamide, >=97% (HPLC);6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine);Bachem 9022;D-Trp LHRH-PEA;
Chemical Name:(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Deslorelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH), engineered to exhibit enhanced potency and stability compared to endogenous GnRH. As a decapeptide, it acts as a superagonist at GnRH receptors, leading to profound effects on the hypothalamic-pituitary-gonadal axis. Its unique biochemical structure makes it a valuable tool in the study of reproductive endocrinology, neuroendocrine signaling, and peptide-receptor interactions. Deslorelin's capacity to modulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion has positioned it as a cornerstone compound in both basic and applied research focused on hormonal regulation and peptide-based signaling pathways.
Reproductive axis research: In experimental endocrinology, deslorelin is widely utilized to probe the mechanisms governing the hypothalamic-pituitary-gonadal axis. Its high affinity for GnRH receptors allows precise modulation of gonadotropin release, facilitating studies on feedback regulation, receptor desensitization, and downstream hormonal cascades. Researchers employ it to investigate the temporal dynamics of LH and FSH secretion, as well as to elucidate the molecular underpinnings of reproductive maturation, fertility control, and gonadal function in various vertebrate models.
Peptide-receptor interaction studies: The well-characterized structure and receptor specificity of deslorelin make it a preferred model compound for examining peptide-receptor binding kinetics and signal transduction. Its use enables detailed analysis of ligand-induced receptor activation, internalization, and desensitization processes. Such studies contribute to a broader understanding of G protein-coupled receptor (GPCR) biology and inform the rational design of novel peptide therapeutics and receptor modulators.
Endocrine disruption modeling: Deslorelin serves as a reference compound in research aimed at characterizing endocrine disruptors and their effects on reproductive signaling. By providing a controlled means to stimulate or suppress pituitary hormone release, it allows for the assessment of environmental or synthetic agents that may interfere with natural GnRH signaling. This application is particularly valuable in toxicological studies and in the development of assays for environmental monitoring of endocrine-active substances.
Peptide drug development: The structural and functional properties of deslorelin inform the design and optimization of next-generation GnRH analogs and peptide-based pharmaceuticals. Its use as a lead compound in structure-activity relationship (SAR) studies supports the identification of critical residues for receptor binding and agonist activity. Insights gained from such research facilitate the engineering of peptide analogs with tailored pharmacokinetic and pharmacodynamic profiles for research and industrial applications.
Analytical method validation: In peptide analytics, deslorelin is frequently employed as a standard or control in the development and validation of chromatographic and mass spectrometric methods. Its defined sequence and stability enable accurate calibration and quantification in peptide detection workflows, supporting robust assay performance in quality control, bioanalytical research, and peptide synthesis verification. This role is essential for ensuring the reliability and reproducibility of analytical results in laboratories focused on peptide chemistry and biotechnology.
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