Teriparatide Acetate is a bone-forming peptide supporting osteoporosis research. Buy Teriparatide peptide online to study bone growth and calcium metabolism.
CAT No: 10-101-54
CAS No:52232-67-4 (net), 99294-94-7 (hydrate)
Synonyms/Alias:PTH (1-34) (human),Human parathormone(1-34),Human PTH(1-34),HPTH-(1-34)
Teriparatide Acetate, a synthetic peptide fragment corresponding to the biologically active N-terminal region of human parathyroid hormone, has garnered significant attention in the field of biochemical and pharmaceutical research. As a potent analog of PTH (1-34), this compound is renowned for its ability to modulate calcium metabolism and bone remodeling processes. Its unique structure and receptor-binding properties make it a valuable tool for investigating cellular signaling pathways, skeletal biology, and the underlying mechanisms of bone turnover. Researchers value Teriparatide Acetate for its stability, solubility, and compatibility with a variety of in vitro and in vivo experimental models, allowing for reproducible and insightful studies. The peptide's ability to mimic endogenous hormone activity while offering precise control over dosing and timing further enhances its utility in a broad spectrum of scientific applications.
Bone Metabolism Research: Teriparatide Acetate is extensively utilized in studies focused on bone metabolism and the dynamic regulation of osteoblast and osteoclast activity. By selectively activating the parathyroid hormone 1 receptor (PTH1R) on target cells, this peptide facilitates detailed exploration of anabolic and catabolic signaling pathways that govern bone formation and resorption. Researchers employ it to dissect the temporal and spatial effects of intermittent versus continuous PTH receptor stimulation, shedding light on the molecular events that drive skeletal adaptation, remodeling, and mineral homeostasis. The robust data generated from these models contribute to a deeper understanding of bone biology and the development of innovative therapeutic strategies for skeletal disorders.
Cellular Signaling Pathway Elucidation: PTH (1-34) analogs, such as Teriparatide Acetate, serve as indispensable tools for unraveling the complexities of G protein-coupled receptor (GPCR) signaling. By engaging PTH1R and initiating downstream cascades involving cyclic AMP, protein kinase A, and other secondary messengers, this compound enables researchers to map intricate signaling networks within bone and non-bone tissues. Investigations leveraging this peptide have revealed critical insights into receptor desensitization, internalization, and cross-talk with other signaling systems, thus advancing the broader field of cell biology and receptor pharmacology.
Tissue Engineering and Regenerative Medicine: Scientists working in tissue engineering harness the properties of Teriparatide Acetate to stimulate osteogenic differentiation and matrix mineralization in cultured progenitor cells. Its capacity to enhance the expression of bone-specific genes and promote the deposition of extracellular matrix components underpins its use in the development of engineered bone constructs and scaffolds. In regenerative medicine research, the peptide is incorporated into biomaterial systems or delivered via controlled-release formulations to optimize local bone regeneration, offering new avenues for repairing critical-size defects and improving the integration of orthopedic implants.
Pharmacological Screening and Drug Discovery: The biological activity of Teriparatide Acetate makes it an ideal reference compound for high-throughput screening platforms and structure-activity relationship studies targeting the parathyroid hormone receptor. By serving as a benchmark agonist, it enables the identification and characterization of novel small molecules, peptides, or biologics with improved efficacy, selectivity, or pharmacokinetic properties. This application accelerates the discovery and optimization of next-generation agents for modulating bone and mineral metabolism, ultimately supporting the advancement of innovative therapeutic pipelines.
Endocrine Research and Hormone Regulation Studies: In the realm of endocrine research, Teriparatide Acetate is frequently employed to investigate the physiological and molecular mechanisms underlying calcium and phosphate homeostasis. Its use in experimental models allows for the controlled manipulation of parathyroid hormone signaling, facilitating studies on hormone feedback loops, receptor expression patterns, and adaptive responses in target organs such as bone, kidney, and intestine. Insights gained from these investigations inform our understanding of endocrine regulation and pathophysiology, providing a foundation for further exploration of metabolic bone diseases and hormone-related disorders. Collectively, these diverse applications highlight the indispensable role of Teriparatide Acetate in advancing bone biology, tissue engineering, pharmacological research, and endocrine science.
1. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
3. TMEM16F and dynamins control expansive plasma membrane reservoirs
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