Icatibant

Icatibant (Firazyr) is a synthetic peptidomimetic drug consisting of ten amino acids, and acts as an effective and specific antagonist of bradykinin B2 receptors. It has been approved in the EU for use in hereditary angioedema, and is under investigation for a number of other conditions in which bradykinin is thought to play a significant role.

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CAT#10-101-163
CAS130308-48-4
Synonyms/AliasHOE 140
M.F/FormulaC59H89N19O13S
M.W/Mr.1304.52
SequenceD-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Tic-Oic-Arg
Labeling TargetB2 bradykinin receptor
ApplicationApproved for use in acute attacks of hereditary angioedema (HAE). Investigated for use/treatment in angioedema, liver disease, and burns and burn infections.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityAntagonist
Biological ActivityIcatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
Areas of InterestHereditary angioedema
FunctionsType 1 angiotensin receptor binding
DiseaseHereditary angioneurotic edema
TargetBradykinin Receptor
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