Gonadorelin Acetate

Gonadorelin is a trophic peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.

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CAT#10-101-19
CAS33515-09-2 (net), 34973-08-5 (acetate)
Synonyms/AliasGnRH; Gonadotropin-releasing hormone; LHRH; Luteinizing hormone-releasing factor acetate (salt) hydrate; Dirigestran; Fertagyl; Gonadoliberin; Hypocrine; Luliberin; Lutrefact; Relefact; Luforan; Lutamin; Lutal;L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide acetic acid
Chemical Nameacetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
M.F/FormulaC55H75N17O13.C2H4O2
M.W/Mr.1242.36
SequenceOne Letter Code: XHWSYGLRPG
Three Letter Code: H-Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.CH3CO2H
Labeling TargetGonadotropin-releasing hormone (GNRH) Receptor
ApplicationGonadorelin is also known as LHRH. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityAgonist
Areas of InterestCardiovascular System & Diseases
Pituitary & Hypothalamic Hormones
DiseaseAmenorrhea;
Diagnostic Test for Gonadotropin Deficiency
TargetGonadotropin-releasing hormone receptor
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