Gonadorelin Acetate stimulates LH and FSH release in fertility research. Purchase Gonadorelin peptide powder from a verified peptide supplier for reproductive studies.
CAT No: 10-101-19
CAS No:33515-09-2 (net), 34973-08-5 (acetate)
Synonyms/Alias:Gonadorelin acetate;34973-08-5;Gonadorelin (acetate);GnRH-I acetate;Gonadorelin acetate anhydrous;499785-55-6;UNII-Z6TK4T303L;Z6TK4T303L;34973-08-5 (acetate);Hypocrine;LH-RH (Human);Cystorelin;Fertiline;Lutrelef;Lutrepulse;Luprolite acetate;Gonadorelin diacetate;71447-49-9;UNII-K56QT79S2O;Luteinizing;ABBOTT-41070;(2S)-N-[(2S)-5-CARBAMIMIDAMIDO-1-[(2S)-2-(CARBAMOYLMETHYLCARBAMOYL)PYRROLIDIN-1-YL]-1-OXOPENTAN-2-YL]-2-{2-[(2S)-2-[(2S)-3-HYDROXY-2-[(2S)-2-[(2S)-3-(1H-IMIDAZOL-4-YL)-2-{[(2S)-5-OXOPYRROLIDIN-2-YL]FORMAMIDO}PROPANAMIDO]-3-(1H-INDOL-3-YL)PROPANAMIDO]PROPANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]ACETAMIDO}-4-METHYLPENTANAMIDE; ACETIC ACID;Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, Luteinizing Hormone-Releasing Hormone (LH-RH), Luteinising Hormone-Releasing Hormone, L HRH, Gonadorelin;LHRH ACETATE;K56QT79S2O;CHEMBL1200511;DTXSID30198161;PLR-4013-V;N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydr;PLR-4013;MFCD01742354;AKOS040763976;AC-8924;AT41855;CS-5289;DA-63864;HY-12555;TS-10352;AY-24031?;NS00022081;
Chemical Name:acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Gonadorelin Acetate is a synthetic decapeptide that mimics the endogenous gonadotropin-releasing hormone (GnRH), a pivotal regulator of the hypothalamic-pituitary-gonadal axis in vertebrates. As a potent agonist of GnRH receptors, Gonadorelin Acetate is widely utilized in biochemical and physiological research to investigate mechanisms of reproductive hormone regulation, signal transduction pathways, and endocrine feedback loops. Its structural fidelity to native GnRH, combined with enhanced stability, makes it an essential reagent for probing neuroendocrine control, characterizing receptor-ligand interactions, and supporting peptide-based assay development.
Endocrine signaling studies: Gonadorelin Acetate serves as a fundamental tool in elucidating the dynamics of GnRH-mediated signaling pathways within the pituitary gland. By inducing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in vitro or in ex vivo tissue models, researchers can dissect the downstream effects of GnRH receptor activation. This enables detailed characterization of intracellular transduction mechanisms, including the roles of specific kinases, second messenger systems, and gene expression patterns that govern reproductive physiology.
Receptor pharmacology research: The compound is routinely employed in receptor binding assays and functional studies to characterize the affinity, specificity, and desensitization properties of GnRH receptors. Its defined sequence and receptor selectivity allow for controlled experiments assessing ligand-receptor interactions, receptor trafficking, and the impact of synthetic analogs or antagonists. Such studies are critical for mapping receptor subtypes, understanding structure-activity relationships, and validating new molecular probes targeting the GnRH axis.
Peptide synthesis and analog development: Gonadorelin Acetate is a valuable reference standard and synthetic template in the design and optimization of novel GnRH analogs. Peptide chemists utilize it to benchmark the activity of modified sequences, evaluate stability enhancements, or introduce site-specific substitutions for structure-function analysis. Its precise sequence provides a reliable foundation for developing agonists or antagonists with tailored pharmacodynamic properties, supporting both academic research and preclinical discovery.
Cell signaling and gene expression analysis: In cellular models, the peptide is used to stimulate GnRH receptors and monitor downstream gene expression changes associated with reproductive hormone biosynthesis and secretion. By applying it to cultured pituitary or hypothalamic cells, investigators can assess transcriptional responses, protein phosphorylation events, and feedback regulation mechanisms. These applications facilitate a deeper understanding of hormonal control at the molecular level and support the identification of novel regulatory factors.
Comparative endocrinology and evolutionary studies: Gonadorelin Acetate is also applied in comparative studies across diverse vertebrate species to investigate evolutionary conservation and divergence within the GnRH signaling system. By examining its effects in various animal models, scientists can explore species-specific receptor responses, adaptation mechanisms, and the evolutionary origins of neuroendocrine regulation. Such research provides valuable insights into the fundamental principles governing reproductive biology and hormone signaling networks.
Recently, several reports of adverse reactions after pulsatile GnRH (gonadorelin hydrochloride) infusion therapy have appeared in the medical literature. Although the cause of these reactions has been associated with GnRH itself, the contributions of impurities and degradation products in the administered drug have not been determined, suggesting that the use of high-purity material may be advantageous in controlling unwanted side effects. This study evaluates the purity and long-term stability of a new GnRH product, gonadorelin acetate (Lutrepulse, Ortho Pharmaceutical Corporation). Both the purity and potency of the drug substance, the lyophilized product for injection, and the reconstituted material that would be transferred to the infusion pump system were monitored using high-performance liquid chromatography. The gonadorelin acetate drug substance was found to be stable for at least 12 months when stored at 24 degrees C in 50% relative humidity, and showed no degradation even under accelerated storage conditions. Similarly, the lyophilized product also showed excellent stability for at least 18 months when stored at 24 degrees C in 50% relative humidity. Upon reconstitution, gonadorelin acetate was found to be stable for at least 45 days when stored at 24 degrees C or 37 degrees C.
Wong, W., Mercorelli, M., DeLuccia, F., Young, R., Lane, P. A., Hoerig, J., & Turan, A. (1990). Stability and purity profile of gonadorelin acetate: a high-purity gonadotropin-releasing hormone. International journal of fertility, 35(5), 302-309.
Gonadotropin-releasing hormone analogues are generally regarded as safe drugs. Gonadorelin acetate has been widely used for the diagnosis of central precocious puberty, and life-threatening reactions to gonadorelin acetate are extremely rare. Herein, we described - to the best of our knowledge - the first pediatric case in which severe anaphylaxis was encountered after intravenous gonadorelin acetate administration. An 8-year-old girl who was diagnosed with central precocious puberty was receiving triptorelin acetate treatment uneventfully for 6 months. In order to evaluate the efficacy of the treatment, an LH-RH stimulation test with gonadorelin acetate was planned. Within 3 min after intravenous administration of gonadorelin acetate, she lost consciousness and tonic seizures began in her hands and feet. She was immediately treated with epinephrine, diphenhydramine, and fluids. Her vital signs recovered within 30 min. Based on the results, anaphylaxis should be anticipated and the administration of these drugs should be performed in a setting that is equipped to deal with systemic reactions.
Akın, O., Yavuz, S. T., Hacıhamdioğlu, B., Sarı, E., Gürsel, O., & Yeşilkaya, E. (2015). Anaphylaxis to gonadorelin acetate in a girl with central precocious puberty. Journal of Pediatric Endocrinology and Metabolism, 28(11-12), 1387-1389.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More