Thymopentin Acetate peptide enhances immune modulation and T-cell function. Purchase Thymopentin research peptide online for immunotherapy and cell biology research.
CAT No: 10-101-33
CAS No:69558-55-0 (net)
Synonyms/Alias:Thymopentin monoacetate; Thymopentin Acetate; 177966-81-3; 89318-88-7; Thymopentin (acetate); UNII-1938Y8P51M; DTXSID80237615; Thymopentin acetate salt H-Arg-Lys-Asp-Val-Tyr-OH acetate salt; 1938Y8P51M; L-Tyrosine, L-arginyl-L-lysyl-L-alpha-aspartyl-L-valyl-, monoacetate (Salt); L-Tyrosine, N-(N-(N-(n2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)-, monoacetate; acetic acid;(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid; Thymopentin acetate salt; MFCD00133107; SCHEMBL270731; HY-N7122A; DTXCID30160106; FT109621; MS-31284; H-Arg-Lys-Asp-Val-Tyr-OH; H-RKDVY-OH; CS-0113786; G12349; Q27252059; Thymopentin acetate (H-L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH.Ac); L-TYROSINE, L-ARGINYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-VALYL-, MONOACETATE (SALT); L-TYROSINE, N-(N-(N-(N2-L-ARGINYL-L-LYSYL)-L-.ALPHA.-ASPARTYL)-L-VALYL)-, MONOACETATE
Thymopentin Acetate is a synthetic pentapeptide corresponding to residues 32-36 of the thymic hormone thymopoietin, widely recognized for its role in modulating immune system activity. As a peptide compound, it is distinguished by its ability to mimic a key functional domain of endogenous thymic factors, making it highly relevant for studies exploring T-cell differentiation, immune signaling, and peptide-receptor interactions. Its well-defined sequence and stability as an acetate salt render it an invaluable tool for researchers investigating the mechanisms underlying immune regulation and peptide-based biomodulation. The compound's unique biochemical properties have positioned it as a standard in immunological assay development and peptide structure-activity relationship analyses.
Immunological research: Thymopentin Acetate is frequently employed in immunology laboratories to elucidate the molecular mechanisms governing T-cell maturation and activation. By providing a defined peptide sequence that interacts with specific cellular receptors, it enables researchers to dissect the signal transduction pathways involved in thymic hormone-mediated immune modulation. Its use in vitro allows for controlled experiments assessing the impact of peptide ligands on lymphocyte proliferation, differentiation, and cytokine production, thereby advancing the understanding of adaptive immunity.
Peptide-receptor interaction studies: Due to its structural homology with thymopoietin's active region, this pentapeptide serves as an ideal probe for investigating the binding characteristics and specificity of thymic peptide receptors. Researchers utilize it to map receptor-ligand interactions, characterize binding affinities, and identify critical amino acid residues responsible for biological activity. These studies provide foundational insights into the design of novel peptide analogues with tailored receptor selectivity or enhanced stability for experimental purposes.
Peptide synthesis and analytical method development: Thymopentin Acetate's well-characterized sequence makes it a valuable reference standard in the optimization of solid-phase peptide synthesis protocols and the validation of analytical techniques such as HPLC and mass spectrometry. Its inclusion in method development workflows aids in establishing process reproducibility, verifying peptide purity, and calibrating detection sensitivity. As a benchmark compound, it supports the advancement of peptide manufacturing and quality control methodologies in both academic and industrial settings.
Cellular signaling pathway elucidation: The compound is utilized in mechanistic studies aimed at unraveling the downstream signaling events initiated by thymic peptides. Researchers apply it to cultured immune cells to monitor changes in intracellular signaling cascades, transcription factor activation, and gene expression profiles. These investigations contribute to a deeper understanding of how short regulatory peptides influence cellular behavior, with implications for the broader field of immunoregulation.
Structure-activity relationship (SAR) analysis: Thymopentin Acetate is integral to SAR studies seeking to correlate specific sequence motifs with biological function. By serving as a model peptide, it enables systematic substitution experiments and comparative analyses with related analogues. Such work is essential for pinpointing the structural determinants of activity and for guiding the rational design of next-generation peptides with improved functional attributes for research use.
Human immature thymocytes express significant levels of the CD10 (endopeptidase 24.11) cell surface antigen. We report here that IOB5, an anti-CD10 mAb, as well as the phorbol ester PMA down-regulate CD10 activity at the surface of human thymocytes. The kinetics of CD10 modulation were drastically different for both effectors, indicating different regulatory mechanisms. We also demonstrated that intact human thymocytes hydrolyze thymopentin and that CD10 significantly participates in this process. Finally, we found that thymopentin and to a lesser extent phosphoramidon, a specific endopeptidase 24.11 inhibitor, induced up-regulation of CD4 and CD8 molecules at the thymocyte cell surface. In view of these results, we suggest that down-regulation of endopeptidase 24.11 at the thymocyte cell surface might reduce its activity toward thymic factors possibly involved in the regulation of thymocyte functions.
Guerin, S., Mari, B., Belhacene, N., Rossi, B., Peyron, J. F., & Auberger, P. (1997). CD10 (endopeptidase 24.11) is a thymic peptide-degrading enzyme possibly involved in the regulation of thymocyte functions. Cellular immunology, 175(1), 85-91.
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