Thymopentin Acetate peptide enhances immune modulation and T-cell function. Purchase Thymopentin research peptide online for immunotherapy and cell biology research.
CAT No: 10-101-33
CAS No:69558-55-0 (net)
Synonyms/Alias:Thymopentin monoacetate; Thymopentin Acetate; 177966-81-3; 89318-88-7; Thymopentin (acetate); UNII-1938Y8P51M; DTXSID80237615; Thymopentin acetate salt H-Arg-Lys-Asp-Val-Tyr-OH acetate salt; 1938Y8P51M; L-Tyrosine, L-arginyl-L-lysyl-L-alpha-aspartyl-L-valyl-, monoacetate (Salt); L-Tyrosine, N-(N-(N-(n2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)-, monoacetate; acetic acid;(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid; Thymopentin acetate salt; MFCD00133107; SCHEMBL270731; HY-N7122A; DTXCID30160106; FT109621; MS-31284; H-Arg-Lys-Asp-Val-Tyr-OH; H-RKDVY-OH; CS-0113786; G12349; Q27252059; Thymopentin acetate (H-L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH.Ac); L-TYROSINE, L-ARGINYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-VALYL-, MONOACETATE (SALT); L-TYROSINE, N-(N-(N-(N2-L-ARGINYL-L-LYSYL)-L-.ALPHA.-ASPARTYL)-L-VALYL)-, MONOACETATE
Thymopentin Acetate is a synthetic pentapeptide derived from the active center of thymopoietin, a thymic hormone known for its significant role in immunomodulation. As a highly stable and water-soluble peptide, Thymopentin Acetate is valued in research settings for its ability to mimic natural biological activities associated with immune system regulation. Its sequence, Arg-Lys-Asp-Val-Tyr, enables targeted interactions with immune cell receptors, making it a versatile tool for investigating immunological mechanisms. Researchers utilize this compound not only for its structural similarity to endogenous peptides but also for its capacity to elicit specific cellular responses, which is critical in the study of immune signaling pathways, cell differentiation, and intercellular communication.
Immunology Research: Thymopentin Acetate serves as a pivotal molecule in immunology research, particularly in the exploration of T-cell maturation and differentiation. By acting as a functional analogue of thymopoietin, it facilitates studies on thymic peptide-mediated signaling and its impact on the development and activation of T lymphocytes. Researchers employ it to dissect the molecular mechanisms underlying immune tolerance, autoimmunity, and the maintenance of immune homeostasis. Its ability to modulate T-cell activity enables the investigation of immune system dysregulation and the identification of novel therapeutic targets for immune-mediated disorders.
Cellular Signaling Pathway Analysis: In the context of cellular signaling, Thymopentin Acetate is utilized to probe the intricate pathways that govern immune cell communication. Its interaction with specific receptors on immune cells triggers downstream effects, such as cytokine release and gene expression changes, which are essential for coordinating immune responses. Scientists leverage this peptide to map out receptor-ligand interactions, signal transduction cascades, and the cross-talk between innate and adaptive immunity. These studies contribute to a deeper understanding of how immune responses are initiated, regulated, and resolved at the cellular level.
Peptide Drug Discovery: The unique immunomodulatory properties of Thymopentin Acetate make it a valuable scaffold in peptide drug discovery efforts. Researchers investigate its structure-activity relationships to design and optimize novel peptide analogues with enhanced stability, specificity, and bioactivity. By modifying its sequence or conjugating it with other bioactive moieties, scientists aim to develop next-generation immunomodulatory agents for experimental applications. The insights gained from these studies inform the rational design of peptides with tailored immune functions, expanding the repertoire of research tools available for immunopharmacology.
Biomarker Development: Thymopentin Acetate is also instrumental in the identification and validation of immunological biomarkers. Its defined activity profile allows for controlled stimulation or inhibition of immune pathways, facilitating the assessment of cellular responses in various experimental models. By monitoring changes in gene expression, protein secretion, or cell surface marker expression following peptide treatment, researchers can pinpoint candidate biomarkers associated with immune activation or suppression. These findings support the development of diagnostic assays and the refinement of experimental protocols in immunological research.
Vaccine Adjuvant Research: In vaccine development studies, Thymopentin Acetate is explored as a potential adjuvant to enhance antigen-specific immune responses. Its immunostimulatory effects can be harnessed to boost the efficacy of experimental vaccines by promoting the activation and proliferation of antigen-presenting cells and T lymphocytes. Researchers assess its ability to modulate the magnitude and quality of immune responses when administered in combination with various antigens. These investigations provide valuable insights into adjuvant mechanisms and contribute to the optimization of vaccine formulations for research purposes.
Through its multifaceted applications, Thymopentin Acetate continues to advance the frontiers of immunological research, offering a robust platform for dissecting immune mechanisms, discovering novel bioactive peptides, and supporting the development of innovative research tools. Its versatility and well-characterized biological activity make it an indispensable asset in studies aimed at understanding and manipulating immune system functions.
Human immature thymocytes express significant levels of the CD10 (endopeptidase 24.11) cell surface antigen. We report here that IOB5, an anti-CD10 mAb, as well as the phorbol ester PMA down-regulate CD10 activity at the surface of human thymocytes. The kinetics of CD10 modulation were drastically different for both effectors, indicating different regulatory mechanisms. We also demonstrated that intact human thymocytes hydrolyze thymopentin and that CD10 significantly participates in this process. Finally, we found that thymopentin and to a lesser extent phosphoramidon, a specific endopeptidase 24.11 inhibitor, induced up-regulation of CD4 and CD8 molecules at the thymocyte cell surface. In view of these results, we suggest that down-regulation of endopeptidase 24.11 at the thymocyte cell surface might reduce its activity toward thymic factors possibly involved in the regulation of thymocyte functions.
Guerin, S., Mari, B., Belhacene, N., Rossi, B., Peyron, J. F., & Auberger, P. (1997). CD10 (endopeptidase 24.11) is a thymic peptide-degrading enzyme possibly involved in the regulation of thymocyte functions. Cellular immunology, 175(1), 85-91.
1. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review
5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More