Somatostatin peptide inhibits the secretion of growth hormone and insulin. Purchase high-purity Somatostatin for metabolic, neuroendocrine, and cancer research.
CAT No: R1683
CAS No:51110-01-1
Synonyms/Alias:SOMATOSTATIN;51110-01-1;Somatostatin-14;SRIF;Somiaton;Stilamin;CCRIS 7071;Panhibin;EINECS 256-969-7;Somatotropin release-inhibiting factor;19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-37-[[2-(2-aminopropanoylamino)acetyl]amino]-13,25,28-tribenzyl-10,16-bis(1-hydroxyethyl)-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carboxylic acid;(D-Trp8,D-Cys14)-Somatostatin-14;Somatostatin (Human, Ovine, Porcine, Rat, Mouse);AY 24910;[D-Trp8]-SOMATOSTATIN;NCGC00181005-01;AGCKNFFWKTFTSC;SCHEMBL3046327;HOR-299;PSI-4023-V;PSI-4101-V;PSI-4023;HB3088;AKOS015896026;DB-051897;L000577;Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-Cys;AGCKNFFWKTFTSC (modifications: Disulfide bridge between 3 - 14);19,34-bis(4-aminobutyl)-37-[2-(2-aminopropanamido)acetamido]-13,25,28-tribenzyl-31-(carbamoylmethyl)-10,16-bis(1-hydroxyethyl)-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane-4-carboxylic acid;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys * 2AcOH * 6H2O; Somatostatin SRIF, Somatostatin-14;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys, Somatostatin SRIF, Somatostatin-14;Growth hormone release-inhibiting factor, SST, SMS, SMST, GHIH, H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, So;
Somatostatin is a regulatory peptide hormone widely recognized for its multifaceted roles in the modulation of endocrine and neuroendocrine signaling. As a cyclic tetradecapeptide, it functions primarily as an inhibitory factor, exerting control over the secretion of numerous other hormones and neurotransmitters. Its presence is notable throughout the central nervous system, pancreas, and gastrointestinal tract, where it orchestrates complex physiological processes. Extensive research into somatostatin has illuminated its significance in cellular communication, signal transduction, and homeostatic regulation, making it a cornerstone molecule in peptide biochemistry and endocrinology.
Peptide signaling research: Somatostatin serves as a model compound for studying peptide-mediated inhibitory signaling pathways in both neuronal and peripheral tissues. Its ability to bind to specific G protein-coupled receptors (somatostatin receptors, SSTRs) allows researchers to dissect the molecular mechanisms underlying receptor-ligand interactions, downstream signal modulation, and feedback inhibition. Investigations utilizing this peptide have advanced understanding of how inhibitory peptides regulate neurotransmitter release, hormone secretion, and synaptic plasticity, providing a foundation for broader neuropeptide research.
Endocrine regulation studies: The peptide's potent ability to suppress the release of growth hormone, insulin, glucagon, and other secretory products positions it as an indispensable tool for probing endocrine feedback loops. Researchers employ somatostatin in experimental systems to elucidate the dynamics of hormone crosstalk and the physiological consequences of altered secretory profiles. Such studies are critical for mapping the regulatory architecture of the hypothalamic-pituitary axis, pancreatic islets, and gastrointestinal hormone networks, deepening insight into hormonal balance and metabolic control.
Receptor pharmacology: Somatostatin is frequently utilized in receptor binding assays and functional studies designed to characterize the pharmacological properties of SSTR subtypes. Through radioligand binding, competitive inhibition, and downstream signaling assays, it provides a benchmark for evaluating receptor affinity, selectivity, and activation profiles. These applications are central to the development of synthetic analogs, receptor modulators, and peptide-based probes, supporting advances in receptor-targeted research and molecular pharmacology.
Peptide synthesis and analog development: As a structurally well-defined cyclic peptide, somatostatin is a reference standard in solid-phase peptide synthesis and analog design. Its unique disulfide-bridged ring structure and sequence motifs offer a template for the development of stable peptide analogs with tailored receptor selectivity or enhanced metabolic stability. Synthetic chemists and peptide engineers leverage somatostatin's properties to refine synthetic methodologies, optimize purification protocols, and evaluate structure-activity relationships in peptide drug design and functional studies.
Cellular signaling analysis: The inhibitory actions of somatostatin on adenylyl cyclase activity, calcium influx, and exocytosis render it a valuable probe in cellular signaling investigations. Researchers use the peptide to modulate intracellular signaling cascades in cultured cells and tissue preparations, facilitating the study of second messenger systems, ion channel regulation, and vesicular trafficking. These experiments contribute to a detailed understanding of how peptide hormones orchestrate cellular responses, adapt to environmental cues, and maintain physiological equilibrium.
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