Luteinizing Hormone-Releasing Hormone (LHRH) and Analogs

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

CAT# Product Name M.W Molecular Formula Inquiry
10-101-04 Antide 1591.32 C82H108ClN17O14 Inquiry
10-101-132 Degarelix 1,630.75 C82H103ClN18O16 Inquiry
10-101-20 Goserelin Acetate 1269.43 C59H84N18O14 Inquiry
10-101-36 Triptorelin Acetate 1371.52 C64H82N18O13.C2H4O2 Inquiry
10-101-94 Ozarelix Acetate 1459.09 C72H96ClN17O14 Inquiry
L08001 LH-RH Sea Bream 1114.2 C52H69N14O14 Inquiry
L08002 LHRH (chicken) 1154.25 C54H71N15O14 Inquiry
L08003 [Gln8] LH-RH, chicken 1154.3 C54H71N15O14 Inquiry
L08005 LHRH 1182.31 C55H75N17O13 Inquiry
L08006 LH-RH, Free Acid 1183.4 C55H74N16O14 Inquiry
L08007 LHRH (salmon) 1212.33 C60H73N15O13 Inquiry
L08008 LH-RH, lamprey 1226.3 C58H79N15O15 Inquiry
L08009 LHRH (lamprey III) 1259.35 C59H74N18O14 Inquiry
L08011 (Trp6)-LHRH 1311.47 C64H82N18O13 Inquiry
L08013 LHRH (7-10) . 2 HCl 513.47 C19H36N8O4 · 2 HCl Inquiry
L08014 LHRH (1-4) (free acid) 539.55 C25H29N7O7 Inquiry
L08015 LHRH (1-5) (free acid) 702.72 C34H38N8O9 Inquiry
L08016 LHRH (4-10) 747.85 C33H53N11O9 Inquiry
L08018 LHRH (1-6) amide 758.79 C36H42N10O9 Inquiry
L08019 LHRH (1-6) (free acid) 759.78 C36H41N9O10 Inquiry

Introduction

Luteinizing hormone-releasing hormone (LHRH), also known as Gonadotropin-releasing hormone (GnRH), is known for its role as the final common signaling molecule by stimulating the synthesis of LH and FSH to regulate reproductive behaviors in all vertebrates. Synthesized in the hypothalamus, LHRH primarily acts on the gonadotrophs in the pituitary gland, which expresses a recognized member of the G-protein coupled, Ca2+-dependent receptor. It also secretes Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH), which together, play a crucial role during puberty to allow both the male and female body to reach sexual maturity which eventually leads to the fertility.

Mechanism of action

The receptors of LHRH are found in breast tumors and pituitary gland in the brain. Moreover, neural plasma membrane is also found to contain specific binding site for LHRH. The mechanism by which LHRH binds to membrane before it binds to the receptors is a very critical step and can have a profound impact upon the translation of peptide across the membrane. A complex form of glycosphingolipids known as Ganglioside is an important component of plasma membrane of nerve cells and breast tumor tissues. They play an important role in various physiological membrane processes. Therefore, the interaction of ganglioside-containing membrane with LHRH might be crucial in aiding the LHRH to translate through the neural membrane and reach its receptor for binding and activation.

Application of Luteinizing Hormone-Releasing Hormones (LHRH) and Analogs

Cytotoxic analogs of LHRH (luteinizing hormone-releasing hormone) can be successfully used for the treatment of hormone-dependent cancers such as prostatic, ovarian, endometrial. Long-term administration of luteinizing hormone-releasing hormone analogs (LHRHa) is the main type of androgen-deprivation therapy (ADT) for lethal prostate cancer. In patients with advanced prostate cancer, LHRH agonists have been shown to achieve improvements in survival, progression-related outcomes, and time-to-treatment failure that are similar to bilateral orchiectomy, a procedure that many patients find psychologically difficult to accept.

References

  1. Meani D., Solarić M., Visapää H., Rosén RM., Janknegt R., &Soče M. (2017). Practical differences between luteinizing hormone-releasing hormone agonists in prostate cancer: perspectives across the spectrum of care. Ther Adv Urol,10(2):51-63.
  2. Oláh G., Dobos N., Vámosi G., Szabó Z., Sipos É., Fodor K., Harda K., Schally AV.,& Halmos G. (2018). Experimental therapy of doxorubicin resistant human uveal melanoma with targeted cytotoxic luteinizing hormone-releasing hormone analog (AN-152). Eur J Pharm Sci, 123:371-376.
  3. Zarrin Shahzadi., Chaitali Mukhopadhyay. (2017). Interaction Between Luteinizing Hormone-Releasing Hormone and GM1-Doped Cholesterol/Sphingomyelin Vesicles: A Spectroscopic Study. The Journal of Membrane Biology, 250(6), 617-627.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Customer Support & Price Inquiry

Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!

  UFP-803 (H-Asp-c[Pen-Phe-DTrp-Dab-Tyr-Cys]-Val-OH), [Pen 5, DTrp 7, Dab 8] U-II (4-11), is a peptidic UT (urote ...

 Taltirelin is a thyrotropin-releasing hormone (TRH) analog that binds the brain BRH receptors in vivo. Taltireli ...

GIP is a 42-aminoacid peptide secreted from the intestinal K-cells (located mainly in the duodenum and proximal jejunum) and ...

 The 70-kDa heat shock protein (HSP70) contains three domains: the ATPase N-domain, which hydrolyses ATP, the sub ...

  Eptifibatide acetate is a white or white-off powder, soluble in water and freely soluble in 1% acetic in water, ...

Quick Inquiry
×
Contact Us

USA

Address:

Tel: |

Email:

Germany

Address:

Copyright © 2024 Creative Peptides. All rights reserved.