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Triptorelin Acetate

Triptorelin acetate is a potent LHRH agonist. It can result in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. For most prostate cancers, they need the hormone testosterone in order to grow. Almost all testosterone in men is made by the testicles. Triptorelin stops the testicles from making testosterone. This reduces testosterone levels and may shrink the prostate cancer or stop it growing.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-36

CAS No:57773-63-4 (net), 140194-24-7 (acetate)

Synonyms/Alias:Triptorelin acetate;140194-24-7;140194-24-7 (acetate);pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 acetate;Decapeptyl (TN);(S)-N-(2-amino-2-oxoethyl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide acetate;UNII-43OFW291R9;BIM 21003C;43OFW291R9;DTXSID301033427;HY-12551A;AKOS030485974;AC-8937;AT41854;FT28582;DA-68354;TS-08149;CS-0012388;D08649;Q27258659;Triptorelin acetate 100 microg/mL in Acetonitrile:Methanol;6-D-Tryptophan luteinizing hormone-releasing factor (swine) acetate;6-D-Tryptophan luteinizing hormone-releasing factor (pig) acetat e;BIM 21003C;

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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C66H86N18O15
M.W/Mr.
1371.5
Sequence
One Letter Code:XHWSYWLRPG
Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2.CH3CO2H
Application
Triptoreline as an antineoplastic (hormonal) is currently used in the treatment of prostatic cancer where therapy may be required over months or years. It is also used in the treatment of endometriosis and infertility.
Appearance
White Solid
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C64H82N18O13.C2H4O2/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44;1-2(3)4/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69);1H3,(H,3,4)/t44-,45-,46-,47-,48+,49-,50-,51-,52-;/m0./s1
InChI Key
HPPONSCISKROOD-OYLNGHKZSA-N

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