Goserelin Acetate

Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.

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CAT No: 10-101-20

CAS No: 145781-92-6

Synonyms/Alias: Goserelin acetate;145781-92-6;Fertilan;Goserelin (acetate);UNII-6YUU2PV0U8;6YUU2PV0U8;Zoladex;DTXSID9046736;Goserelin acetate [JAN];DTXCID7026736;MFCD01747329;GOSERELIN ACETATE (MART.);GOSERELIN ACETATE [MART.];GOSERELIN ACETATE (USP-RS);GOSERELIN ACETATE [USP-RS];GOSERELIN ACETATE (USP MONOGRAPH);GOSERELIN ACETATE [USP MONOGRAPH];CAS-145781-92-6;Novgos;Zoladex LA;Acetate, Goserelin;Goserelin Acetate; 1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-, 2-(aminocarbonyl)hydrazide, acetate (salt) (9CI); Luteinizing hormone-releasing factor (pig), 6-[O-(1,1-dimethylethyl)-D-serine]-10-deglycinamide-, 2-(aminocarbonyl)hydrazide, acetate (salt); Fertilan;(D-Ser(tBu)6,Azagly10)-LHRH acetate;NCGC00167588-02;NCGC00183275-01;SCHEMBL6094;CHEMBL1200501;GOSERELIN ACETATE [VANDF];IKDXDQDKCZPQSZ-JHYYTBFNSA-N;65807-02-5 , Goserelin;GLXC-26187;GOSERELIN ACETATE [WHO-DD];Tox21_112579;Tox21_112937;BDBM50247974;HY-13673A;ICI118630;NSC606864;AKOS040758435;CS-4509;FG44023;GOSERELIN ACETATE [ORANGE BOOK];ICI118630?;MS-32115;D-Ser(bu(t))(6)azgly(10)-LHRH Acetate;F85210;Goserelin acetate, >=99% (HPLC), white powder;Q27265738;Goserelin, European Pharmacopoeia (EP) Reference Standard;H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNHCONH2 AcOH;Goserelin acetate, United States Pharmacopeia (USP) Reference Standard;Goserelin for NMR identification, European Pharmacopoeia (EP) Reference Standard;ZDX;

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC61H88N18O16
M.W/Mr.1329.5
SequenceOne Letter Code:XHWSYXLRP
Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNHCONH2.CH3CO2H
ApplicationGoserelin acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Areas of InterestCancer Research, Pituitary & Hypothalamic Hormones, Veterinary Medicine
Source#Synthetic
Solubility−20°C
InChIInChI=1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1
InChI KeyIKDXDQDKCZPQSZ-JHYYTBFNSA-N

1. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

2. Cationic cell-penetrating peptides are potent furin inhibitors

3. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

4. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

5. P-selectin and Complement’s Role in a Neonatal Model of Germinal Matrix Hemorrhage-Induced Secondary Injury

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