Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.
|Synonyms/Alias||(D-Ser(tBu)6; Azagly10)-LHRH; goserelin; Zoladex; Decapeptide I; Goserelin acetate; Gosereline; Goserelinum; Goserelina; Goserelin; ICI 118630; ICI-118630; ICI118630|
|Sequence||Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 acetate salt|
|Application||Goserelin acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.|
|Areas of Interest||Cancer Research, Pituitary & Hypothalamic Hormones, Veterinary Medicine|
||Long-term Storage Conditions||−20°C
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