Buserelin Acetate is an agonist of gonadotropin-releasing hormone receptor(GnRHR). Buserelin is a synthetic luteinizing hormone–releasing hormone (LHRH) analog.
CAT# | 10-101-07 |
CAS | 57982-77-1 (net), 68630-75-1 (acetate) |
Background | Buserelin is a synthetic analog of gonadotropin-releasing hormone (GnRH). It binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. |
Synonyms/Alias | (Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH; Bigonist; HOE-766; HOE766; HOE 766; Profact; Receptal; Suprecur; Suprefact; Tiloryth; Hoe-766 MP; Hoe766 MP; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-L-proline ethylamide acetic acid |
Chemical Name | acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
M.F/Formula | C62H90N16O15 |
M.W/Mr. | 1299.48 |
Sequence | One Letter Code: XHWSYXLRP Three Letter Code: H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt.CH3CO2H |
Labeling Target | Gonadotropin-releasing hormone (GNRH) receptor |
Application | Buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Agonist |
Biological Activity | Buserelin Acetate is a gonadotropin-releasing hormone agonist (GnRH agonist). |
Areas of Interest | Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones |
Functions | Luteinizing hormone receptor activity |
Target | GNRH Receptor |
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