Carbidopa

Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism oflevodopa. This property is significant in that it allows a greater proportion of peripheral levodopa to cross the blood–brain barrier for central nervous system effect.

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CAT#	10-101-135
CAS	28860-95-9 (net), 38821-49-7 (monohydrate)
Synonyms/Alias	lodosyn; CARBIDOPA 1-HYDRATE; CARBIDOPA MONOHYDRATE; (S)-3-(3,4-Dihydroxyphenyl)-2- hydrazino-2-methylpropanoic acid · H2O; (S)-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid monohydrate; (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate; α-Methyldopahydrazine monohydrate; MK485, MK 485, MK-485, Carbidopa, Lodosyn
Chemical Name	(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
M.F/Formula	C10H14N2O4
M.W/Mr.	226.23 (net); 244.25 (monohydrate)
Sequence	One Letter Code: X Three Letter Code: N(NH2)aMeTyr(3-OH)-OH
Labeling Target	Aromatic-L-amino-acid decarboxylase; Tyrosine-protein kinase Lck; Tyrosine-protein kinase Fyn; Lysine-specific demethylase 4E
Application	Parkinson's disease
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Inhibitor
Areas of Interest	Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones
Target	Aromatic-L-amino-acid decarboxylase

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Source#	Synthetic
Solubility	Soluble in DMSO, not in water
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
InChI Key	QTAOMKOIBXZKND-PPHPATTJSA-N
Canonical SMILES	CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
Isomeric SMILES	C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN.O
BoilingPoint	528.7ºC at 760 mmHg
ShelfLife	>2 years if stored properly
Melting Point	N/A