Lepirudin

Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. Lepirudin is a highly specific direct inhibitor of thrombin.

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CAT#10-101-90
CAS138068-37-8 (net)
Synonyms/Alias(Leu1,Thr2)-Hirudin (desulfated); Lepirudin; Refludan; Refludin; Hbw 023; Hbw-023; Hbw023
M.F/FormulaC287H440N80O111S6
M.W/Mr.6979.52
SequenceLTYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ(Disulfide bridge: 6-14; 16-28; 22-39)
Labeling TargetProthrombin
ApplicationLepirudin is used for the treatment of heparin-induced thrombocytopenia
ActivityInhibitor
Biological ActivityLepirudin is an anticoagulant that functions as a direct thrombin inhibitor.
Areas of InterestCardiovascular System & Diseases
Hematology
FunctionsThrombospondin receptor activity
DiseaseThrombosis in Heparin Induced Thrombocytopenia
TargetThrombin
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