Ganirelix

Ganirelix acetate (or diacetate) is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH.

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CAT#	10-101-61
Chemical Structure
CAS	123246-29-7
Synonyms/Alias	Antagon; orgalutran; RS 26306; RS-26306; RS26306; Ganirelixum; LS-181948; LS181948; LS 181948
Chemical Name	(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
M.F/Formula	C80H113ClN18O13
M.W/Mr.	1570.4
Sequence	One Letter Code: XXXSYXLXPA Three Letter Code: Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-hArg(Et,Et)-Leu-hArg(Et,Et)-Pro-D-Ala-NH2
Labeling Target	Gonadotropin-releasing hormone (GNRH) Receptor
Application	Ganirelix is primarily used in assisted reproduction to control ovulation.
Activity	Antagonist
Biological Activity	Ganirelix is a gonadotropin releasing hormone (GnRH) antagonist. It blocks a natural hormone called GnRH that typically releases other hormones to prepare your body for ovulation (release of an egg from your ovary). By blocking GnRH, ganirelix temporarily delays ovulation. It's used to prevent eggs from being released too early and can help your provider be more successful during your egg retrieval procedure.
Areas of Interest	Endocrinology
Functions	Peptide binding
Disease	Ovulation induction
Target	Gonadotropin-releasing hormone (GnRH)

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-19	Gonadorelin Acetate	1242.36	C55H75N17O13.C2H4O2	Inquiry
10-101-21	Histrelin Acetate	1383.6	C66H86N18O12	Inquiry
10-101-66	Kassinin	1334.54	C59H95N15O18S	Inquiry
10-101-86	Gonadorelin Hydrochloride	1218.76	C55H75N17O13	Inquiry
10-101-87	GRF (human) Acetate	5039.72	C215H358N72O66S	Inquiry

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-20	Goserelin Acetate	1269.43	C59H84N18O14	Inquiry
10-101-59	Liraglutide	3751.2	C172H265N43O51	Inquiry
R1574	Octreotide	1019.24	C₄₉H₆₆N₁₀O₁₀S₂	Inquiry
10-101-139	Myrcludex B			Inquiry
10-101-285	Teduglutide	3752.08	C164H252N44O55S	Inquiry
R1847	Sermaglutide	4114	C187H291N45O59	Inquiry
R1961	Carbetocin	988.2	C45H69N11O12S	Inquiry

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Source#	Synthetic
Long-term Storage Conditions	−20°C
Organism	Human
InChI	InChI=1S/C80H113ClN18O13/c1-9-84-79(85-10-2)88-38-17-15-24-60(70(104)94-62(41-49(5)6)71(105)93-61(25-16-18-39-89-80(86-11-3)87-12-4)78(112)99-40-20-26-68(99)77(111)90-50(7)69(82)103)92-73(107)64(44-53-30-35-59(102)36-31-53)97-76(110)67(48-100)98-75(109)66(46-55-21-19-37-83-47-55)96-74(108)65(43-52-28-33-58(81)34-29-52)95-72(106)63(91-51(8)101)45-54-27-32-56-22-13-14-23-57(56)42-54/h13-14,19,21-23,27-37,42,47,49-50,60-68,100,102H,9-12,15-18,20,24-26,38-41,43-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,91,101)(H,92,107)(H,93,105)(H,94,104)(H,95,106)(H,96,108)(H,97,110)(H,98,109)(H2,84,85,88)(H2,86,87,89)/t50-,60-,61+,62+,63-,64+,65-,66-,67+,68+/m1/s1
InChI Key	GJNXBNATEDXMAK-PFLSVRRQSA-N
Canonical SMILES	CCNC(=NCCCCC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN=C(NCC)NCC)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C)NCC
Isomeric SMILES	CCNC(=NCCCC[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC3=CN=CC=C3)NC(=O)[C@@H](CC4=CC=C(C=C4)Cl)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)NC(=O)C)NCC
BoilingPoint	N/A
Melting Point	N/A