Fertirelin Acetate is a synthetic peptide that promotes ovulation and fertility. Purchase Fertirelin research peptide for breeding and hormonal studies.
CAT No: 10-101-17
CAS No:38234-21-8 (net)
Synonyms/Alias:(Des-Gly10,Pro-NHEt9)-LHRH; Fertirelin; Fertirelina; Fertireline; Fertirelinum
Chemical Name:acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Fertirelin Acetate, a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH), is widely recognized for its potent agonist activity and structural stability. Designed to mimic the natural hypothalamic hormone, Fertirelin Acetate features enhanced resistance to enzymatic degradation, making it a valuable tool in research settings that require precise control over reproductive hormone signaling. Its robust activity profile, coupled with reliable solubility in aqueous solutions, allows for consistent and reproducible experimental outcomes. As a result, Fertirelin Acetate has become a staple in studies focused on reproductive biology, endocrine regulation, and neuroendocrine communication, enabling scientists to dissect complex hormonal pathways with accuracy and confidence.
Reproductive Endocrinology Research: Fertirelin Acetate serves as a critical reagent in the exploration of pituitary-gonadal axis regulation. By stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, it facilitates the study of feedback mechanisms and hormone secretion dynamics. Researchers utilize Fertirelin Acetate in both in vitro and in vivo models to evaluate the physiological consequences of GnRH receptor activation, providing insights into the molecular underpinnings of fertility, puberty onset, and gonadal function.
Neuroendocrine Signaling Studies: The application of this GnRH analog extends to investigations of neuroendocrine communication between the brain and reproductive organs. Its ability to precisely activate GnRH receptors allows for the mapping of neuronal circuits involved in hormone release and reproductive behavior. Scientists leverage Fertirelin Acetate to delineate the roles of specific hypothalamic regions, neurotransmitters, and receptor subtypes in the modulation of reproductive hormone pulses, advancing our understanding of the neurobiological basis of reproduction.
Animal Reproductive Management Research: In animal science, Fertirelin Acetate is frequently employed to synchronize ovulation and investigate the timing of reproductive events in various species. Its use enables the controlled induction of ovulatory surges, which is essential for studies on breeding efficiency, seasonal reproductive cycles, and the impact of environmental factors on fertility. By providing a reliable means to manipulate reproductive timing, researchers can optimize protocols for animal husbandry and genetic selection experiments.
Endocrine Disruptor Testing: The synthetic peptide is also instrumental in assessing the effects of environmental contaminants on reproductive health. By establishing a baseline response to GnRH stimulation, Fertirelin Acetate allows scientists to evaluate how exposure to endocrine-disrupting chemicals alters hormonal signaling pathways. This application is crucial for toxicology studies aiming to identify substances that interfere with reproductive hormone synthesis, secretion, or receptor function, thereby contributing to environmental safety and public health research.
Signal Transduction Pathway Elucidation: Fertirelin Acetate is utilized in cellular and molecular biology to dissect the intracellular signaling cascades triggered by GnRH receptor engagement. Researchers employ the peptide to activate downstream effectors such as protein kinases, transcription factors, and second messengers, enabling the characterization of gene expression changes and cellular responses associated with reproductive hormone regulation. These studies are fundamental for identifying novel molecular targets and understanding the broader implications of GnRH signaling in health and disease.
Peptide analogs like Fertirelin Acetate have paved the way for significant advancements in reproductive science, neuroendocrinology, and molecular endocrinology. Its versatility and robust activity profile make it an indispensable tool for dissecting the intricate hormonal networks that govern reproductive processes. Whether used to model pituitary responses, probe neuroendocrine circuits, synchronize reproductive cycles in animal studies, assess the impacts of environmental disruptors, or map intracellular signaling pathways, Fertirelin Acetate continues to facilitate high-impact research and foster new discoveries across multiple scientific disciplines.
The effect of using a dose of 50 micro g rather than 100 micro g fertirelin in an ovulation/fixed-time insemination protocol for Holstein-Friesian dairy cows was investigated in three experiments. In each experiment, fertirelin was administered at the beginning of the protocol followed 7 days later by 500 micro g cloprosterol. Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus. The effect on conception rate was studied in experiment 1 using 114 postpartum anoestrus cows. There was no significant difference in the age, parity or number of days after parturition in each treatment groups. The conception rate did not differ between the 50 micro g fertirelin group (61.1%; n=72) and the 100 micro g group (59.5%; n=42; NS). In experiment 2, a further 12 cows at 40-60 days postpartum were treated with 100 or 50 micro g fertirelin (n=6 per dose) with treatment commencing in the follicular or luteal phase of the oestrous cycle. The plasma concentration of luteinizing hormone (LH) reached similar peaks of over 5 ng/ml 120 min after the intramuscular administration of fertirelin in both groups. There were no significant differences in LH levels between treatments or phase of the oestrous cycle when treatment commenced. Doses of 50 and 100 micro g fertirelin were compared in experiment 3 using 17 cows to study follicular wave development and synchronization by transrectal ultrasonography, conception rate and corpus luteum function. There were no significant differences between treatments for these factors. It was concluded that using a dose of 50 micro g fertirelin enabled the drug costs to be reduced without affecting the efficiency of a synchronization of ovulation/fixed-time AI protocol for dairy cows.
Yamada, K., Nakao, T., Nakada, K., & Matsuda, G. (2002). Influence of GnRH analogue (fertirelin acetate) doses on synchronization of ovulation and fixed-time artificial insemination in lactating dairy cows. Animal reproduction science, 74(1), 27-34.
The optimum dose for establishing superovulation in mice of Fertirelin Acetate (FA), an LH-RH analogue, was examined. Mice were subcutaneously injected with 5 IU of hCG at 17:00 (Day 0), and with various doses of FA (0.001 to 1.0 microg) five times at 4 h intervals on and after 22:00 on Day 0. To induce ovulation, 5 IU of hCG was again injected subcutaneously at 17:00 on Day 2. In the groups administered with doses ranging from 0.01 to 0.5 microg of FA, the number of ovulated eggs was significantly (p<0.05) larger than in the control group (12.9 +/- 5.9). The greatest number of ovulated eggs (22.6 +/- 7.3) was obtained in the group administered with 0.025 microg of FA. The results indicate that the effective dose of LH-RH analogue, FA, is between 0.1 and 0.5 microg for superovulation induction in mice.
Nariai, K., Ishinazaka, T., Suzuki, K., UCHIYAMA, H., SATO, K., ASANO, R., ... & KANAYAMA, K. (2005). Optimum dose of LH-RH analogue Fertirelin Acetate for the induction of superovulation in mice. Experimental animals, 54(1), 97-99.
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