Angiotensin II peptide regulates blood pressure and vascular constriction. Purchase this synthetic research peptide to support cardiovascular and renal function studies.
CAT No: HB00117
CAS No:68521-88-0
Synonyms/Alias:ANGIOTENSIN II;4474-91-3;Angiotensin II human;Hypertensin;Human angiotensin II;Angiotensin II (human);Ang II;5-L-Isoleucineangiotensin II;Angiotensin II, human;5-Isoleucine-angiotensin II;Angiotensin II (mouse);Giapreza;Asp-Arg-Val-Tyr-Ile-His-Pro-Phe;1-8-Angiotensin I;Ile(5)-angiotensin II;Isoleucine5-angiotensin II;CHEBI:2719;Delivert;angiotensine II;ANG-(1-8)Octapeptide;isoleucine(5)-angiotensin II;UNII-M089EFU921;DRVYIHPF;Ile5-angiotensin II;Angiotensin II, 5-L-isoleucine-;1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide;Angiotensin II (human type);CHEMBL408403;LJPC-501;Angiotensinum II;Angiotensin II acetate salt;L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine;L-Phenylalanine, N-(1-(N-(N-(N-(N-(N2-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-;N-(1-(N-(N-(N-(N-(N(2)-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine;(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-5-((S)-sec-butyl)-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-((diaminomethylene)amino)propyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid;(3S)-3-AMINO-3-{[(1S)-4-CARBAMIMIDAMIDO-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL}PYRROLIDIN-1-YL]-3-(1H-IMIDAZOL-4-YL)-1-OXOPROPAN-2-YL]CARBAMOYL}-2-METHYLBUTYL]CARBAMOYL}-2-(4-HYDROXYPHENYL)ETHYL]CARBAMOYL}-2-METHYLPROPYL]CARBAMOYL}BUTYL]CARBAMOYL}PROPANOIC ACID;Alanine, N-(1-(N-(N-(N-(N-(N2-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-3-phenyl-, L-;Angiotensinum II (INN-Latin);Angiotensin cento, human;Angiotensina II (INN-Spanish);Angiotensin II, ile(5)-;Angiotensin ii [INN:JAN];Angiotensin 2;Angiotensin-(1-8) Octapeptide;Delivert (TN);C50H71N13O12;Angiotensin II heavy;Angiotensin II (9CI);Angiotensin II (USAN);ANGIOTENSIN II,HUMAN;SCHEMBL1189;Angiotensin II (acetate);Ang II (acetate);DRVYIHPF (acetate);GTPL2504;SCHEMBL9013957;DTXSID4036778;SCHEMBL20502357;CHEBI:48432;C01CX09;DTXSID30196288;CHEBI:131170;ty-10721;M089EFU921;Angiotensin II (human type) (JAN);BDBM50228195;BDBM50236697;HB3488;AKOS016010178;DB11842;FA73187;NCGC00167130-01;DA-70862;HY-13948;NS00074073;Asp1-Arg2-Val3-Tyr4-Ile5-His6-Pro7-Phe8;C02135;C75211;D02014;DRVY-I*-HPF [I*= I(13C6,15N)];EN300-19742056;Q412999;32044-01-2, 4474-91-3 (salt);ANG-(1-8)Octapeptide, Hypertensin, 4474-91-3, Giapreza;Conalbumin (328-332), 1226776-54-0, RVPSL peptide;ProteoMass(TM) Angiotensin II MALDI-MS Standard, vial of 10 nmol;(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-4-yl)methyl)-17-amino-5-((S)-sec-butyl)-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid;(3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid;L-phenylalanine, L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-;
Angiotensin II is a potent octapeptide hormone within the renin-angiotensin system, recognized for its critical role in regulating vascular tone and fluid balance. As a bioactive peptide, Angiotensin II exerts diverse physiological effects, primarily through binding to specific angiotensin receptors distributed throughout various tissues. Its unique structure enables selective interaction with these receptors, leading to complex intracellular signaling cascades that influence both short-term and long-term physiological responses. Because of its well-characterized mechanism of action and receptor specificity, Angiotensin II is extensively utilized in a wide range of research and laboratory applications, providing valuable insights into cardiovascular, renal, and endocrine system functions.
Cardiovascular physiology research: In cardiovascular studies, Angiotensin II serves as a fundamental tool for investigating mechanisms underlying blood pressure regulation and vascular reactivity. Researchers employ this peptide to induce vasoconstriction in isolated vessel models, allowing detailed examination of smooth muscle cell responses, endothelial function, and the interplay between vascular tone and systemic hemodynamics. Its ability to elicit robust and reproducible changes in vascular resistance makes it indispensable for dissecting the molecular pathways involved in hypertension and vascular remodeling.
Renal function studies: Angiotensin II is frequently applied in renal physiology experiments to elucidate its influence on glomerular filtration, tubular reabsorption, and sodium balance. By administering the peptide in in vitro and in vivo models, scientists can observe its effects on renal blood flow, mesangial cell contraction, and the modulation of key transporters in nephron segments. Such studies are instrumental in clarifying the peptide's role in the regulation of fluid homeostasis and the pathogenesis of kidney diseases.
Signal transduction and receptor pharmacology: The use of Angiotensin II in cellular and molecular biology extends to the analysis of intracellular signaling pathways triggered by angiotensin receptors. Researchers leverage it to activate G protein-coupled receptor cascades, monitoring downstream events such as calcium mobilization, protein kinase activation, and gene expression changes. These investigations not only deepen understanding of receptor pharmacodynamics but also facilitate the identification of novel modulators and antagonists with potential therapeutic relevance.
Endocrine system modulation: In studies focused on hormone regulation, Angiotensin II is employed to probe its effects on the secretion of aldosterone, vasopressin, and other hormones integral to electrolyte and water balance. Experimental protocols often involve exposing adrenal or pituitary cell cultures to the peptide, enabling quantification of hormone release and assessment of feedback mechanisms. This application is particularly valuable for mapping the intricate networks that coordinate cardiovascular and renal endocrine responses.
Tissue remodeling and inflammation research: Angiotensin II is also utilized in models examining tissue remodeling, fibrosis, and inflammatory processes. Its capacity to stimulate cellular proliferation, matrix protein synthesis, and the release of pro-inflammatory mediators makes it a key agent in studies of organ fibrosis, vascular injury, and chronic disease progression. By manipulating exposure conditions and analyzing resultant cellular behaviors, scientists gain critical insights into the molecular drivers of pathological tissue changes and potential intervention strategies.
Angiotensin II thus stands as a versatile and indispensable reagent across multiple fields of biomedical research. Its well-defined biological actions and receptor interactions support a broad spectrum of experimental designs, from elucidating fundamental physiological processes to exploring the mechanisms of disease progression. By enabling precise modulation of signaling pathways and physiological responses, it continues to drive advancements in our understanding of cardiovascular, renal, endocrine, and tissue remodeling phenomena, fostering the development of innovative research tools and therapeutic concepts.
1. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
2. TMEM16F and dynamins control expansive plasma membrane reservoirs
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More