Leuprolide acetate (Leuprorelin acetate) is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Synonyms/Alias | Leuprolide acetate;Leuprorelin acetate;Lupron;74381-53-6;Carcinil;Lucrin;Eligard;Enantone;Leuplin;Viadur;Lupron Depot;Abbott-43818;Prostap;TAP-144;Fensolvi;Leuprin;Lupaneta;Procrin;Trenantone;Leuplin depot;Lutrate depot;Procren Depot;Uno-Enantone;Depo-Lupron;LUPRON DEPOT-PED;Leuporelin acetate;Lupron PED;TAP-144-SR;Leuprolide Monoacetate;Enanton;Lutrate;Leuprolide acetate depot;LUPRON DEPOT-3;LUPRON DEPOT-4;Abbott 43818;CHEBI:63597;UNII-37JNS02E7V;37JNS02E7V;A-43818;Leuprolide (Acetate);DTXSID7049009;Leuprolide acetate [USAN:USP];DTXCID2028935;Leuprolide acetate [USAN];des-Gly10-[D-Leu6]-LH-RH ethylamide;Leuprolide acetate (USAN:USP);LEUPROLIDE ACETATE (USP-RS);LEUPROLIDE ACETATE [USP-RS];LEUPRORELIN ACETATE (MART.);LEUPRORELIN ACETATE [MART.];MFCD00072080;LEUPRORELIN ACETATE [JAN];LEUPROLIDE ACETATE (USP MONOGRAPH);LEUPROLIDE ACETATE [USP MONOGRAPH];Acetate, Leuprolide;LEUP;MFCD00167544;Ginecrin;Onectyl;Procren;Depo-Eligard;Enantone-Gyn;Fensolvi Kit;Lucrin Depot;Lupron Depot Ped;Leuprolide Acetate?;Lupron Depot-Ped Kit;ELIGARD KIT;Lupron Depot-3 Month;Lupron Depot-4 Month;LUTRATE DEPOT KIT;NCGC00183364-01;SCHEMBL3174;MLS000028695;CHEMBL1200775;LEUPROLIDE ACETATE [VANDF];LEUPROLIDE MONOACETATE [MI];Tox21_113507;BDBM50247891;LEUPRORELIN ACETATE [WHO-DD];s3718;AKOS015895632;AKOS030485977;CCG-270666;CS-1434;FL24877;LEUPROLIDE ACETATE [ORANGE BOOK];5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tryosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate (salt);AC-28731;HY-13665;SMR000058945;CAS-74381-53-6;L0249;(Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH acetate;Leuprolide Acetate (53714-56-0 free base);Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt.HOAc;Q27104908;PGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHC2H5 ACETATE SALT;5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TRYOSYL-D-LEUCYL-L-LEUCYL-L-ARGINYL-N-ETHYL-L-PROLINAMIDE ACETATE (SALT);5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tryosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate;5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide--acetic acid (1/1);6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing hormone-releasing factor acetate;L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-, acetate (1:1); |
M.F/Formula | C61H88N16O14 |
M.W/Mr. | 1269.4 |
Sequence | One Letter Code:XHWSYLLRP Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt.CH3CO2H |
Activity | Agonist |
Target | Gonadotropin-releasing hormone receptor |
Long-term Storage Conditions | H2O : ≥ 66.66 mg/mL (52.51 mM) |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
InChI | InChI=1S/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40;1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64);1H3,(H,3,4)/t40-,41-,42-,43+,44-,45-,46-,47-,48-;/m0./s1 |
InChI Key | RGLRXNKKBLIBQS-XNHQSDQCSA-N |
1. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
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