Topotecan Hydrochloride
Topotecan Hydrochloride is the water-soluble hydrochloride salt preparation of Topotecan, a potent inhibitor of topoisomerase 1, and an apoptosis inducer, producing proapoptotic and antiproliferative effects. Topotecan is a semisynthetic derivative of the natural product alkaloid camptothecin. It is described to stabilize topoisomerase I/DNA cleavable complexes and promote rapid apoptotic cell death in radiation-resistant human B-lineage acute lymphoblastic leukemia cells.
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| CAT# | 10-101-124 |
| CAS | 123948-87-8 (net), 119413-54-6 (hydrochloride) |
| Synonyms/Alias | TPT; SKF-104864A; SKFS-104864-A; 9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin · HCl; (S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2b]quinoline-3,14(4H,12H)-dione · HCl; (20S)-10-Dimethylaminomethyl-4-ethyl |
| M.F/Formula | C23H23N3O5 |
| M.W/Mr. | 421.44 |
| Labeling Target | DNA topoisomerase |
| Application | Ovarian cancer & Cervical cancer & Small cell lung cancer (SCLC) |
| Activity | Inhibitor |
| Biological Activity | Topotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. |
| Areas of Interest | Cancer treatment |
| Functions | Poly(a) rna binding |
| Disease | Small cell carcinoma of lung
Malignant tumor of cervix
Malignant tumor of ovary |
| Source# | Synthetic |
Organism | Human |
InChI | InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 |
InChI Key | UCFGDBYHRUNTLO-QHCPKHFHSA-N |
Isomeric SMILES | CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O |
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