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Sincalide Ammonium Salt

Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) and acts on receptors within the gallbladder wall causing it to contract.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-31

CAS No:25126-32-3 (net)

Synonyms/Alias:CCK-8; Cholecystokinin Octapeptide; (Des-Pyr1,Des-Gln2,Met5)-Caerulein

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cGMP Peptide
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M.F/Formula
C49H62N10O16S3
M.W/Mr.
1143.3
Sequence
Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
Labeling Target
Gastrin/cholecystokinin receptor
Application
Sincalide ammonium salt is used for the diagnosis of bile tract and pancreatic diseases, and for the clinical radiology of the intestinal tract.
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Biological Activity
Sincalide ammonium (Cholecystokinin octapeptide ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is an agent that promotes gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders.
Areas of Interest
Cardiovascular System & Diseases
Pituitary & Hypothalamic Hormones
Source#
Synthetic
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions
Dry, dark and at 0 - 4 °C
Solubility
-20 °C
BoilingPoint
N/A
ShelfLife
>2 years if stored properly
References

To establish normal gallbladder ejection fraction (GBEF) values for two sincalide (cholecystokinin [CCK]) infusion dose rates, 0.01 microg per kilogram of body weight infused for 3 minutes and 0.01 microg/kg infused for 60 minutes.

Ziessman, H. A., Muenz, L. R., Agarwal, A. K., & ZaZa, A. A. (2001). Normal values for sincalide cholescintigraphy: comparison of two methods. Radiology, 221(2), 404-410.

Melting Point
N/A

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