Sincalide Ammonium Salt

Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) and acts on receptors within the gallbladder wall causing it to contract.

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CAT No: 10-101-31

CAS No: 25126-32-3 (net)

Synonyms/Alias: CCK-8; Cholecystokinin Octapeptide; (Des-Pyr1,Des-Gln2,Met5)-Caerulein

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M.F/FormulaC49H62N10O16S3
M.W/Mr.1143.3
SequenceAsp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
Labeling TargetGastrin/cholecystokinin receptor
ApplicationSincalide ammonium salt is used for the diagnosis of bile tract and pancreatic diseases, and for the clinical radiology of the intestinal tract.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Biological ActivitySincalide ammonium (Cholecystokinin octapeptide ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is an agent that promotes gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders.
Areas of InterestCardiovascular System & Diseases
Pituitary & Hypothalamic Hormones
Source#Synthetic
Long-term Storage ConditionsSoluble in DMSO
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage ConditionsDry, dark and at 0 - 4 °C
Solubility-20 °C
BoilingPointN/A
ShelfLife>2 years if stored properly
References

To establish normal gallbladder ejection fraction (GBEF) values for two sincalide (cholecystokinin [CCK]) infusion dose rates, 0.01 microg per kilogram of body weight infused for 3 minutes and 0.01 microg/kg infused for 60 minutes.

Ziessman, H. A., Muenz, L. R., Agarwal, A. K., & ZaZa, A. A. (2001). Normal values for sincalide cholescintigraphy: comparison of two methods. Radiology, 221(2), 404-410.

Melting PointN/A
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