Angiotensin II is an octapeptide that produced from angiotensin I after the removal of two amino acids at the C-terminal by angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity.
CAT# | 10-101-03 |
CAS | 4474-91-3 (net) |
Synonyms/Alias | Angiotensin II; Ang II |
Chemical Name | acetic acid;(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid |
M.F/Formula | C52H75N13O14 |
M.W/Mr. | 1106.2 |
Sequence | H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH |
Labeling Target | Angiotensin Receptor |
Application | Use as a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | An Angiotensin II Type 1 and Type 2 Receptor Agonist. |
Areas of Interest | Cardiovascular Disease |
Functions | Protein heterodimerization activity |
Target | Type-1 angiotensin II receptor |
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