Angiotensin II is an octapeptide that produced from angiotensin I after the removal of two amino acids at the C-terminal by angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity.
CAT# | 10-101-03 |
CAS | 4474-91-3 (net) |
Synonyms/Alias | Angiotensin II; Ang II |
Chemical Name | acetic acid;(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid |
M.F/Formula | C52H75N13O14 |
M.W/Mr. | 1106.2 |
Sequence | H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH |
Labeling Target | Angiotensin Receptor |
Application | Use as a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | An Angiotensin II Type 1 and Type 2 Receptor Agonist. |
Areas of Interest | Cardiovascular Disease |
Functions | Protein heterodimerization activity |
Target | Type-1 angiotensin II receptor |
Source# | Synthetic | Solubility | Soluble in DMSO, not in water | Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. | Short-term Storage Conditions | Dry, dark and at 0 - 4 °C | Long-term Storage Conditions | -20 °C | Organism | Human | InChI | InChI=1S/C50H71N13O12.C2H4O2/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66;1-2(3)4/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55);1H3,(H,3,4)/t28-,33-,34-,35-,36-,37-,38-,40-,41-;/m0./s1 | InChI Key | VBTZKFAHKJXHBA-PIONDTTLSA-N | Canonical SMILES | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N.CC(=O)O | Isomeric SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N.CC(=O)O | BoilingPoint | N/A | ShelfLife | >2 years if stored properly | Melting Point | N/A |
CAT# | Product Name | M.W | Molecular Formula | Inquiry |
---|---|---|---|---|
10-101-25 | Brain Natriuretic Peptide, Human | 3464.09 | C143H244N50O42S4 | Inquiry |
10-101-53 | Eledoisin | 1188.4 | C54H85N13O15S | Inquiry |
10-101-55 | Rotigaptide | 617.65 | C28H39N7O9 | Inquiry |
10-101-70 | Argipressin | 1084.21 | C46H65N15O12S2 | Inquiry |
10-101-82 | Endothelin-1 (human, bovine, dog, mouse, porcine, rat) Acetate | 2491.94 | C109H159N25O32S5 | Inquiry |
10-101-90 | Lepirudin | 6979.52 | C287H440N80O111S6 | Inquiry |
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