Nafarelin
Nafarelin acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
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| CAT# | 10-101-211 |
| CAS | 76932-56-4, 76932-60-0, 86220-42-0 |
| Synonyms/Alias | (D-2-Nal6)-LHRH; RS-94991-298; Synarel; Nafarelinum; Nafarelina; Nafarelin; Nafarelin acetate; LS-88237 |
| M.F/Formula | C66H83N17O13 |
| M.W/Mr. | 1322.47 |
| Application | Three Letter Code: Pyr-His-Trp-Ser-Tyr-D-2-Nal-Leu-Arg-Pro-Gly-NH2 |
| Activity | Agonist |
| Biological Activity | Synthetic gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Repeated administration causes desensitization of pituitary GnRH receptors resulting in inhibition of gonadotropin release and decreased steroid hormone synthesis. Induces atrophy and regression of experimentally induced endometriosis in rat and shrinks hypertrophic tissue in benign prostatic hyperplasia. |
| Target | Gonadotropin-releasing hormone (GnRH) |
| Storage | Desiccate at -20°C |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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