- Home
- COVID-19
- Services
- Products
- Research Areas
- Company
- Resources
- Ordering
Adefovir Dipivoxil is a acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI). It is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.
| CAT# | 10-101-107 |
| CAS | 142340-99-6 |
| Synonyms/Alias | Adefovir di(pivaloyloxymethyl) ester;Bis(POM)PMEA; GS-0840; Piv2PMEA;9-[2-(Bis[(pivaloyloxy)-methoxy]phosphinylmethoxy)ethyl]adenine |
| Chemical Name | [2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate |
| M.F/Formula | C20H32N5O8P |
| M.W/Mr. | 501.48 |
| Sequence | no |
| Labeling Target | DNA polymerase/reverse transcriptase |
| Application | For treatment of hepatitis B and herpes simplex virus infection |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Biological Activity | Adefovir Dipivoxil is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV). |
| Areas of Interest | Infection |
| Functions | Rna-dna hybrid ribonuclease activity |
| Disease | Chronic type B viral hepatitis |
| Target | HBV |
* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
