Adefovir Dipivoxil

Adefovir Dipivoxil is a acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI). It is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.

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Synonyms/AliasAdefovir di(pivaloyloxymethyl) ester;Bis(POM)PMEA; GS-0840; Piv2PMEA;9-[2-(Bis[(pivaloyloxy)-methoxy]phosphinylmethoxy)ethyl]adenine
Chemical Name[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
Labeling TargetDNA polymerase/reverse transcriptase
ApplicationFor treatment of hepatitis B and herpes simplex virus infection
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Biological ActivityAdefovir Dipivoxil is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).
Areas of InterestInfection
FunctionsRna-dna hybrid ribonuclease activity
DiseaseChronic type B viral hepatitis
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