Everolimus is a Kinase Inhibitor and mTOR Inhibitor Immunosuppressant. The mechanism of action of everolimus is as a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor and P-Glycoprotein Inhibitor and Cytochrome P450 2D6 Inhibitor and mTOR Inhibitor. The physiologic effect of everolimus is by means of Decreased Immunologic Activity.
Afinitor; Certican; Zortress; RAD001; SDZ-RAD
Serine/threonine-protein kinase mTOR
Everolimus is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
White to off-white solid powder
>98% (or refer to the Certificate of Analysis)
Areas of Interest
Tfiiic-class transcription factor binding
Carcinoma of breast; Renal cell carcinoma; Prevention of Kidney Transplant Rejection; Pancreatic Neuroendocrine Tumor
Soluble in DMSO, not in water
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.