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APIs

Everolimus

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CAT#
Z10-101-155
Synonyms/Alias
Afinitor; Certican; Zortress; RAD001; SDZ-RAD
CAS No.
159351-69-6
M.W/Mr.
958.24
Molecular Formula
C53H83NO14
Application
Everolimus is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Description
Everolimus is a Kinase Inhibitor and mTOR Inhibitor Immunosuppressant. The mechanism of action of everolimus is as a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor and P-Glycoprotein Inhibitor and Cytochrome P450 2D6 Inhibitor and mTOR Inhibitor. The physiologic effect of everolimus is by means of Decreased Immunologic Activity.
Areas of Interest
Kinase Inhibitor
Storage
−20°C

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